HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Krombach, G. A. Articles by Buecker, A. Search for Related Content PubMed PubMed Citation Articles by Krombach, G. A. Articles by Buecker, A.

MR-guided Percutaneous Intramyocardial Injection with an MR-compatible Catheter: Feasibility and Changes in T1 Values after Injection of Extracellular Contrast Medium in Pigs¹

¹ From the Departments of Diagnostic Radiology (G.A.K., J.G.P., M.K., R.W.G., A.B.) and Experimental Veterinary Medicine (S.K.), University Hospital of the University of Technology, Pauwelstrasse 30, 52057 Aachen, Germany. Received October 31, 2003; revision requested January 26, 2004; final revision received July 9; accepted August 17. Address correspondence to G.A.K. (e-mail: krombach@rad.rwth-aachen.de)

PURPOSE: To assess the feasibility of percutaneous magnetic resonance (MR)-guided intramyocardial injection of gadodiamide by using real-time imaging and to quantify T1 values and the size of the enhanced region for different concentrations of contrast agent for 30 minutes after injection.

MATERIALS AND METHODS: Animal care committee approval was obtained. A catheter with a needle tip was advanced into the left ventricle in seven pigs by using real-time imaging with radial steady-state free precession. After intramyocardial injection of 2 mL of solution at concentrations of 0.05 or 0.10 mmol/mL gadodiamide, local changes in T1 values and size of the contrast material–enhanced region were sequentially measured at 3, 15, and 30 minutes after injection by using the Look-Locker sequence. Two-tailed paired Student t tests were used for statistical analysis.

RESULTS: Catheter guidance and visualization of contrast agent distribution were feasible in all animals. Regional changes in T1 values were significantly different for different contrast agent concentrations (for 0.05 mmol/mL, 456 msec ± 5 [± standard error of the mean]; for 0.10 mmol/mL, 228 msec ± 4; P < .001) measured 3 minutes after injection. T1 values increased significantly (P < .05) to 720 msec ± 7 for 0.05 mmol/mL gadodiamide and 445 msec ± 6 for 0.10 mmol/mL gadodiamide 30 minutes after injection but remained significantly lower than those of remote myocardium (879 msec ± 8). The size of the contrast-enhanced region increased from 13 mm² ± 2 at 3 minutes to 30 mm² ± 3 at 30 minutes (P < .05).

CONCLUSION: Catheter MR-guided percutaneous intramyocardial injection is feasible; after intramyocardial injection of gadodiamide at concentrations of 0.05 and 0.10 mmol/mL, T1 values decreased over the observation time.

© RSNA, 2005

This article has been cited by other articles:

				S. Nazarian, A. Kolandaivelu, M. M. Zviman, G. R. Meininger, R. Kato, R. C. Susil, A. Roguin, T. L. Dickfeld, H. Ashikaga, H. Calkins, et al. Feasibility of Real-Time Magnetic Resonance Imaging for Catheter Guidance in Electrophysiology Studies Circulation, July 15, 2008; 118(3): 223 - 229. [Abstract] [Full Text] [PDF]

				M. Saeed, A. J. Martin, R. J. Lee, O. Weber, D. Revel, D. Saloner, and C. B. Higgins MR Guidance of Targeted Injections into Border and Core of Scarred Myocardium in Pigs Radiology, August 1, 2006; 240(2): 419 - 426. [Abstract] [Full Text] [PDF]

				D. S. Baim and R. Y. Kwong Is Magnetic Resonance Image Guidance the Key to Opening Chronic Total Occlusions? Circulation, February 28, 2006; 113(8): 1053 - 1055. [Full Text] [PDF]

				R. J. Lederman Cardiovascular Interventional Magnetic Resonance Imaging Circulation, November 8, 2005; 112(19): 3009 - 3017. [Full Text] [PDF]