HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2361040923v1 236/1/112    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mahnken, A. H. Articles by Buecker, A. Search for Related Content PubMed PubMed Citation Articles by Mahnken, A. H. Articles by Buecker, A.

Acute Myocardial Infarction: Assessment of Left Ventricular Function with 16–Detector Row Spiral CT versus MR Imaging—Study in Pigs¹

¹ From the Department of Diagnostic Radiology, Aachen University of Technology, Pauwelsstrasse 30, D-52074 Aachen, Germany. Received May 25, 2004; revision requested August 9; revision received August 21; accepted October 5. Address correspondence to A.H.M. (e-mail: mahnken{at}rad.rwth-aachen.de).

PURPOSE: To assess global left ventricular (LV) function and regional wall motion with retrospective electrocardiographically gated 16–detector row computed tomography (CT) in comparison with magnetic resonance (MR) imaging.

MATERIALS AND METHODS: In 15 pigs (mean weight, 53.9 kg ± 9.5 [standard deviation]), acute myocardial infarction was induced with balloon occlusion of the left anterior descending coronary artery after approval was obtained from the committee on animal affairs. Thereafter, multi–detector row CT and MR imaging were performed with standardized examination protocols. From manually drawn endocardial and epicardial contours, LV volumes, including mean ejection fraction, peak filling rate (PFR), peak ejection rate (PER), time to PER, and time from end systole to PFR, were calculated. Regional wall motion was assessed from cine loops with a 16-segment model of the left ventricle. LV function was analyzed by using Bland-Altman plots, Student t test, and Pearson correlation coefficient. Regional wall motion scores were compared with weighted statistic.

RESULTS: LV volumes determined with multi–detector row CT correlated well with MR imaging results, with an ejection fraction of 46.1% ± 6.5 for multi–detector row CT and 46.8% ± 5.9 for MR imaging (r = 0.97). PER, PFR, time to PER, and time from end systole to PFR showed a wide range of scattering and significant differences between multi–detector row CT and MR imaging for PER and time from end systole to PFR (P < .05). Regional wall motion scores showed a very high level of agreement with a value of 0.88.

CONCLUSION: Although 16–detector row CT allows reliable assessment of LV volumes and regional wall motion at rest, it is not suited for assessment of all functional parameters.

© RSNA, 2005

This article has been cited by other articles:

				D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, et al. Noninvasive Coronary Artery Imaging: Magnetic Resonance Angiography and Multidetector Computed Tomography Angiography: A Scientific Statement From the American Heart Association Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention, and the Councils on Clinical Cardiology and Cardiovascular Disease in the Young Circulation, July 29, 2008; 118(5): 586 - 606. [Full Text] [PDF]

				H DOGAN, W J H VELDKAMP, P DIBBETS-SCHNEIDER, A M SPIJKERBOER, B J A MERTENS, L J M KROFT, A DE ROOS, and J GELEIJNS Effects of heart rate, filling and slice thickness on the accuracy of left ventricular volume measurements in a dynamic cardiac phantom using ECG-gated MDCT Br. J. Radiol., July 1, 2008; 81(967): 577 - 582. [Abstract] [Full Text] [PDF]

				C. Plumhans, G. Muhlenbruch, A. Rapaee, K.-H. Sim, T. Seyfarth, R. W. Gunther, and A. H. Mahnken Assessment of Global Right Ventricular Function on 64-MDCT Compared with MRI Am. J. Roentgenol., May 1, 2008; 190(5): 1358 - 1361. [Abstract] [Full Text] [PDF]

				K. Nieman, M. D. Shapiro, M. Ferencik, C. H. Nomura, S. Abbara, U. Hoffmann, H. K. Gold, I.-K. Jang, T. J. Brady, and R. C. Cury Reperfused Myocardial Infarction: Contrast-enhanced 64-Section CT in Comparison to MR Imaging Radiology, April 1, 2008; 247(1): 49 - 56. [Abstract] [Full Text] [PDF]

				H. Wen, K. A. Marsolo, E. E. Bennett, K. S. Kutten, R. P. Lewis, D. B. Lipps, N. D. Epstein, J. F. Plehn, and P. Croisille Adaptive Postprocessing Techniques for Myocardial Tissue Tracking with Displacement-encoded MR Imaging Radiology, January 1, 2008; 246(1): 229 - 240. [Abstract] [Full Text] [PDF]

				H. Brodoefel, U. Kramer, A. Reimann, C. Burgstahler, S. Schroeder, A. Kopp, and M. Heuschmid Dual-Source CT with Improved Temporal Resolution in Assessment of Left Ventricular Function: A Pilot Study Am. J. Roentgenol., November 1, 2007; 189(5): 1064 - 1070. [Abstract] [Full Text] [PDF]

				L. Sugeng, V. Mor-Avi, L. Weinert, J. Niel, C. Ebner, R. Steringer-Mascherbauer, F. Schmidt, C. Galuschky, G. Schummers, R. M. Lang, et al. Quantitative Assessment of Left Ventricular Size and Function: Side-by-Side Comparison of Real-Time Three-Dimensional Echocardiography and Computed Tomography With Magnetic Resonance Reference Circulation, August 15, 2006; 114(7): 654 - 661. [Abstract] [Full Text] [PDF]

				P. K. Woodard Can Multi-Detector Row Spiral CT Be Used to Assess Left Ventricular Function? Radiology, July 1, 2005; 236(1): 1 - 2. [Full Text] [PDF]