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DOI: 10.1148/radiol.2362041363
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(Radiology 2005;236:685-693.)
© RSNA, 2005

Thoracic Imaging

Pleural Disease in Silicosis: Pleural Thickening, Effusion, and Invagination1

Hiroaki Arakawa, MD, Koichi Honma, MD, Yoshiaki Saito, MD, Hisao Shida, MD, Hiroshi Morikubo, MD, Narufumi Suganuma, MD and Mutsuhisa Fujioka, MD

1 From the Departments of Radiology (H.A., M.F.) and Pathology (K.H.), Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan; Departments of Respiratory Medicine (Y.S.) and Radiology (H.S., H.M.), Keihai Rosai Hospital for Silicosis, Nikko, Japan; and Department of Environmental Health, Fukui Medical School, Fukui, Japan (N.S.). Received August 4, 2004; revision requested October 8; revision received November 2; accepted November 12. Address correspondence to H.A. (e-mail: arakawa{at}dokkyomed.ac.jp).

PURPOSE: To retrospectively evaluate pleural disease on images from patients with autopsy-proved silicosis.

MATERIALS AND METHODS: The study had institutional review board approval, and informed consent from relatives of diseased subjects was waived. Lung specimens were obtained at autopsy in 110 men (mean age, 72 years) who had been followed up radiologically for a mean of 14.8 years. Computed tomographic (CT) scans obtained within 2 years before death were examined for presence of pleural thickening; shape, composition, size, and subpleural location of progressive massive fibrosis (PMF); and pleural invagination (bandlike structure between lesion and pleura). Lung specimens were reviewed and compared with CT findings. Serial chest radiographs and CT scans were reviewed for presence of pleural effusion. Association between radiographic findings and pleural invagination was analyzed with {chi}2 and Student t tests. Multiple logistic regression analysis was used to find predictive variables for pleural invagination.

RESULTS: Pleural effusion was found in 12 (11%) patients at chest radiography and CT, and thickening was found in 64 (58%) patients at CT; the latter finding was significantly more frequent with complicated silicosis (P < .001). At CT, 128 PMF lesions were seen, 39 (30%) of which showed pleural invagination; CT scans showed pleural thickening in 36 (92%) of these 39 lesions. In 17 (44%) PMF lesions, CT scans depicted a bandlike structure that was pathologically confirmed to represent invaginated pleura in all cases. Pathologic presence of invagination was significantly associated with pleural thickening (P < .001), ipsilateral pleural effusion (P < .01), interstitial fibrosis (P < .05), and the nearness of PMF to the pleura (P < .005). Multiple logistic regression analysis showed that pleural thickening (odds ratio, 62.51; 95% confidence interval [CI]: 5.564, 70.2) and pleural effusion (odds ratio, 25.865; 95% CI: 1.992, 335.8) were significant CT variables associated with presence of pathologic pleural invagination (P = .001 and .013, respectively). Five PMF lesions had radiographic features of rounded atelectasis.

CONCLUSION: Various pleural abnormalities can occur in silicosis, especially in advanced disease.

© RSNA, 2005




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