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Myocardial Infarct: Depiction with Contrast-enhanced MR Imaging—Comparison of Gadopentetate and Gadobenate¹

¹ From the Departments of Diagnostic and Interventional Radiology (T.S., P.H., C.U.H., H.L., S.M., J.B.) and Cardiology (A.L.), University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany. Received February 5, 2004; revision requested April 13; final revision received October 3; accepted October 22. Address correspondence to J.B. (e-mail: joerg.barkhausen{at}uni-essen.de).

Institutional review board approval and patient written informed consent were obtained. On two separate occasions, 24 hours apart, contrast-enhanced cardiac magnetic resonance (MR) imaging was performed prospectively at 1, 3, 5, 10, and 20 minutes after injection of gadopentetate dimeglumine and gadobenate dimeglumine in 15 patients (11 men, four women) with history of myocardial infarction. Both agents allowed detection of infarcted myocardium. T1 values at all times were significantly (P < .05) lower for gadobenate, compared with values for gadopentetate, in both infarcted and noninfarcted myocardium. At 1 minute after administration of both agents, T1 values in left ventricular cavity (LVC) were not different; at 3–20 minutes after injection, values were significantly (P < .05) lower for gadobenate. Differences between contrast-to-noise ratio (CNR) values of infarcted and noninfarcted myocardium were significantly higher on gadobenate-enhanced images (P < .05). CNR values between infarcted myocardium and LVC were significantly higher on gadopentetate-enhanced images (P < .05). Gadopentetate might permit better delineation of infarcts, especially subendocardial infarcts.

© RSNA, 2005

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				F. Sardanelli, M. Quarenghi, T. Schlosser, and J. Barkhausen Delayed Enhancement of Subendocardial Infarcted Myocardium with Gadobenate Dimeglumine: A Paradoxical Effect--Is a Double Dose Too Much? Radiology, September 1, 2006; 240(3): 914 - 916. [Full Text] [PDF]