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DOI: 10.1148/radiol.2372041403
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(Radiology 2005;237:670-674.)
© RSNA, 2005

Technical Developments

Small-Bowel Perfusion Measurement: Feasibility with Single-Compartment Kinetic Model Applied to Dynamic Contrast-enhanced CT1

Arkadiusz Sitek, PhD and Robert G. Sheiman, MD

1 From the Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215. Received August 13, 2004; revision requested October 13; revision received November 22; accepted December 24. Address correspondence to R.G.S. (e-mail: rsheiman{at}BIDMC.harvard.edu).

This study was institutional review board approved and HIPAA compliant. Informed consent was obtained from all patients. The purpose of the study was to prospectively examine the feasibility of measuring small-bowel quantitative blood flow by using motion-corrected, contrast-enhanced computed tomographic (CT) images and a single-compartment kinetic model. Seven patients underwent abdominal CT in which 40 10-mm-thick sections were obtained at a single level. Small-bowel images were obtained every 3 seconds after contrast agent administration. Automated application of regions of interest yielded time-enhancement curves for the bowel wall and the aorta. A one-compartment model was applied to each set of time-enhancement curves for determination of the small-bowel volumetric blood flow FV, volume of distribution VD, and blood transit time {tau}. FV was also calculated by using the first-pass method and {gamma} variate analysis for model validation. The FV values obtained by using the single-compartment model (mean FV, 0.47 min–1) showed excellent linear correlation with those obtained by using the first-pass method (Pearson r = 0.80) and {gamma} variate analysis (Pearson r = 0.97). Mean VD and {tau} values were 2.86 (unitless) and 4.28 seconds, respectively. A one-compartment kinetic model can be applied to motion-corrected, contrast-enhanced small-bowel CT images to quantify perfusion.

© RSNA, 2005




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