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Human Myocardium: Single-Breath-hold MR T1 Mapping with High Spatial Resolution—Reproducibility Study¹

¹ From the BHF Cardiac MRI Unit (D.R.M., S.P., T.R.J., M.U.S.) and Department of Medical Physics (D.M.H., J.P.R.), Leeds General Infirmary, Leeds, England; and Division of Genomic Medicine, University of Sheffield, Sheffield, England (K.W.). Received November 10, 2004; revision requested January 5, 2005; revision received February 15; accepted March 8; final version accepted May 2. D.M. supported by a Marie Curie Fellowship grant by the European Commission. Address correspondence to D.R.M., Cardiac MRI Unit, Franz-Volhard-Klinik, Charité, Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany. (e-mail: daniel.messroghli{at}charite.de).

A prospective study approved by the local ethics committee was performed to establish the normal range and reproducibility of myocardial T1 values as assessed with single-breath-hold T1 mapping with high spatial resolution. With a 1.5-T magnetic resonance (MR) imaging system, baseline and contrast material–enhanced modified Look-Locker inversion recovery, or MOLLI, imaging was performed in 15 healthy volunteers who had given written informed consent. Image quality scores and myocardial T1 values were derived for standard short-axis segments and sections. Results were compared with those from a second MR imaging study performed on the same day (baseline only) and those from a third study performed on a different day (baseline and contrast enhanced; eight volunteers). Intra- and interobserver agreement were determined. Myocardial T1 maps were obtained rapidly in a reproducible fashion. A normal range for baseline and postcontrast myocardial T1 was established (baseline mean T1 in short-axis sections, 980 msec ± 53 [standard deviation]; 95% confidence interval: 964, 997; number of sections, 43). This technique could enable direct quantification of changes in tissue characteristics in ischemic and inflammatory myocardial diseases.

© RSNA, 2006

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