Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published online before print December 21, 2005, 10.1148/radiol.2381042193

(Radiology 2005;238:531.)

A more recent version of this article appeared on December 1, 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow All Versions of this Article:
2381042193v1
238/2/531    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, Y. K.
Right arrow Articles by Lee, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, Y. K.
Right arrow Articles by Lee, J. M.
© RSNA, 2005

Gastrointestinal Imaging

Hepatocellular Carcinoma in Patients with Chronic Liver Disease: Comparison of SPIO-enhanced MR Imaging and 16–Detector Row CT1

Young Kon Kim, MD, Hyo Sung Kwak, MD, Chong Soo Kim, MD, Gyung Ho Chung, MD, Young Min Han, MD and Jeong Min Lee, MD

1 From the Department of Diagnostic Radiology, Chonbuk National University Medical School and Hospital, Jeonju, Korea (Y.K.K., H.S.K., C.S.K., G.H.C., Y.M.H.); and Department of Radiology, Seoul National University College of Medicine, 28, Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea (J.M.L.). Received December 27, 2004; revision requested February 24, 2005; revision received April 21; accepted May 27; final version accepted July 1. Address correspondence to J.M.L. (e-mail: leejm{at}radcom.snu.ac.kr).

Purpose: To compare the sensitivity, positive predictive value, and diagnostic accuracy of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging with those of 16–detector row computed tomography (CT) for the detection of hepatocellular carcinoma (HCC) in patients with hepatitis B–induced cirrhosis.

Materials and Methods: Institutional Review Board approval was obtained for this study, and informed consent was obtained from all patients. A total of 44 patients (36 men, eight women; age range, 35–67 years) with 59 HCCs and mild liver cirrhosis (Child-Pugh score A or B) underwent multiphasic CT and SPIO-enhanced MR imaging. The diagnosis of HCC was established at surgical resection (n = 31) and percutaneous biopsy (n = 28). SPIO-enhanced MR imaging was composed of T2-weighted turbo spin-echo and T2*-weighted gradient-echo sequences. Multiphasic CT consisted of four phases (ie, early arterial, late arterial, portal venous, and equilibrium). Three observers independently analyzed each image in random order. Sensitivity, positive predictive value, and diagnostic accuracy were calculated by using the alternative free-response receiver operating characteristic analysis for multi–detector row CT and SPIO-enhanced MR imaging.

Results: Although not significant (P > .05), the area under the receiver operating characteristic curve for SPIO-enhanced MR imaging (mean, 0.90) was higher than that for multi–detector row CT (mean, 0.82) for all observers. Also, although no significant difference was demonstrated by any of the three observers (P > .05), there was a trend toward increased sensitivity on both a per-lesion and a per-patient basis for SPIO-enhanced MR imaging (mean, 84.7% and 94.7%, respectively) compared with multi–detector row CT (mean, 76.9% and 88.6%, respectively). No significant difference in positive predictive value was observed between modalities.

Conclusion: SPIO-enhanced MR imaging and multiphasic CT show similar diagnostic accuracy, sensitivity, and positive predictive value for the detection of HCC in patients with relatively mild hepatitis B–induced cirrhosis.

© RSNA, 2005