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Published online before print February 21, 2006, 10.1148/radiol.2383041592
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(Radiology 2006;239:269-275.)
© RSNA, 2006

Technical Developments

Hepatocellular Carcinoma: Microwave Ablation with Multiple Straight and Loop Antenna Clusters—Pilot Comparison with Pathologic Findings1

Nam C. Yu, MD, David S. K. Lu, MD, Steven S. Raman, MD, Damian E. Dupuy, MD, Caroline J. Simon, MD, Charles Lassman, MD, Bassam I. Aswad, MD, David Ianniti, MD and Ronald W. Busuttil, MD, PhD

1 From the Departments of Radiological Sciences (N.C.Y., D.S.K.L., S.S.R.), Pathology (C.L.), and Surgery (R.W.B.), David Geffen School of Medicine at UCLA, BR-158 CHS, Box 951721, 10833 Le Conte Ave, Los Angeles, CA 90095-1721; and the Departments of Diagnostic Imaging (D.E.D., C.J.S.), Pathology (B.I.A.), and Surgery (D.I.), Brown Medical School, Providence, RI. Received September 14, 2004; revision requested November 19; revision received March 1, 2005; accepted March 16; final version accepted May 4. Supported by Vivant Medical, Mountain View, Calif. Address correspondence to D.S.K.L.

The purpose of this study was to evaluate the clinical implementation of triangular and spherical designs for simultaneous multiple-antenna ablation of human hepatocellular carcinoma (HCC) with a recently engineered microwave coagulation system. Institutional review board approval and informed consent were obtained, and the study was compliant with HIPAA requirements. Nine patients (five men, four women; age range, 53–79 years; mean age, 66.2 years) with resectable HCC (diameter, 2.9–6.0 cm; mean, 4.2 cm) underwent intraoperative ultrasonography-guided tumor ablation followed by resection and pathologic examination. Standard single-straight (n = 2), triangular triple-straight (n = 4), and spherical triple-loop (n = 3) antenna configurations produced mean estimated coagulation volumes of 16.7, 51.7, and 54.3 cm3, respectively, during a single concurrent 5–10-minute ablation cycle. The triple-loop configuration yielded the most uniformly round ablation shape. Simultaneous activation of multiple straight or loop antennae is a potentially promising technique for rapid and effective treatment of large HCCs.

© RSNA, 2006




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[Abstract] [Full Text] [PDF]