HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2393042218v1 240/1/116    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kim, S. H. Articles by Choi, B. I. Search for Related Content PubMed PubMed Citation Articles by Kim, S. H. Articles by Choi, B. I.

Hepatic Macrosteatosis: Predicting Appropriateness of Liver Donation by Using MR Imaging—Correlation with Histopathologic Findings¹

¹ From the Department of Radiology (S.H.K., J.M.L., J.K.H., J.Y.L., K.H.L., C.J.H., K.S. Shin, B.I.C.), Institute of Radiation Medicine (J.M.L., J.K.H., B.I.C.), Department of Surgery (J.Y.J., N.J.Y., K.S. Suh), and Department of Pathology (S.Y.J.), Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea; Department of Radiology, Seoul National University Bundang Hospital, Seoul, Korea (K.H.L.); and Chungnam National University Hospital, DaeJeon, Korea (K.S. Shin). Received December 31, 2004; revision requested March 9, 2005; revision received March 23; accepted April 1; final version accepted August 1. Address correspondence to J.M.L. (e-mail: leejm{at}radcom.snu.ac.kr).

Purpose: To retrospectively evaluate the diagnostic performance of magnetic resonance (MR) imaging in predicting the appropriateness of liver donation in potential living liver donors by using histopathologic results as the reference standard.

Materials and Methods: This study was approved by institutional review board; all patients gave informed consent for the use of MR data for future research. Fifty-seven potential liver donors (40 male, 17 female; age range, 17–57 years; mean age, 32 years) underwent dual-echo 1.5-T MR imaging. Two radiologists qualitatively graded each MR image, with consensus for disagreements. Livers were assigned one of three degrees of hepatic steatosis on the basis of changes in hepatic signal intensity (SI) between in-phase and opposed-phase images. For quantitative analysis, a third radiologist calculated mean hepatic and mean splenic SI by averaging 25 hepatic regions of interest and three splenic regions of interest. Relative SI decrease (RSID) in the liver on opposed-phase images compared with in-phase images was calculated. Linear regression analysis was used to correlate RSID with the degree of total steatosis, macrosteatosis, and microsteatosis. Diagnostic performance for predicting the appropriateness of liver donation was analyzed.

Results: Histologic findings of macrosteatosis resulted in 52 patients being categorized as appropriate donors, with the remaining five being categorized as inappropriate donors. RSID was correlated with total steatosis (r = 0.850). When the RSID criterion for inappropriateness of liver donation was set at 20%, the sensitivity, specificity, and accuracy were 100%, 92.3%, and 93%, respectively. When RSID was used, four livers that had been misclassified as inappropriate for transplantation were found to have microsteatosis of various degrees and a less than moderate degree of macrosteatosis at histologic analysis. Qualitative and quantitative analyses were comparably accurate.

Conclusion: When an RSID criterion of less than 20% was used, dual-echo MR imaging facilitated the correct prediction of appropriateness of liver donation in 53 of 57 patients.

© RSNA, 2006

This article has been cited by other articles:

				A. Nickkholgh, J. Weitz, J. Encke, P. Sauer, A. Mehrabi, M. W. Buchler, J. Schmidt, and P. Schemmer Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature Nephrol. Dial. Transplant., September 1, 2007; 22(suppl_8): viii29 - viii36. [Abstract] [Full Text] [PDF]

				S. W. Lee, S. H. Park, K. W. Kim, E. K. Choi, Y. M. Shin, P. N. Kim, K. H. Lee, E. S. Yu, S. Hwang, and S.-G. Lee Unenhanced CT for Assessment of Macrovesicular Hepatic Steatosis in Living Liver Donors: Comparison of Visual Grading with Liver Attenuation Index Radiology, August 1, 2007; 244(2): 479 - 485. [Abstract] [Full Text] [PDF]