Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print May 9, 2006, 10.1148/radiol.2401050739
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2401050739v1
240/1/177    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Petrella, J. R.
Right arrow Articles by Doraiswamy, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Petrella, J. R.
Right arrow Articles by Doraiswamy, P. M.
(Radiology 2006;240:177-186.)
© RSNA, 2006

Neuroradiology

Mild Cognitive Impairment: Evaluation with 4-T Functional MR Imaging1

Jeffrey R. Petrella, MD, Sriyesh Krishnan, BA, Melissa J. Slavin, PhD, Thanh-Thu T. Tran, BS, Lakshmi Murty, BS and P. Murali Doraiswamy, MD

1 From the Department of Radiology, Brain Imaging and Analysis Center (J.R.P., S.K., M.J.S., T.T.T.T., L.M.) and the Departments of Psychiatry and Medicine (Geriatrics) (P.M.D.), Duke University Medical Center, Box 3808, Durham, NC 27710-3808. Received May 1, 2005; revision requested June 30; revision received August 15; accepted September 13; final version accepted October 10. Supported by National Institute on Aging grant R01AG019728. Address correspondence to J.R.P. (e-mail: jeffrey.petrella{at}duke.edu).

Purpose: To prospectively assess abnormalities in brain activation patterns during encoding and retrieval in subjects with mild cognitive impairment by using 4-T functional magnetic resonance (MR) imaging.

Materials and Methods: The institutional review board approved this HIPAA-compliant study; all subjects gave written informed consent. Twenty patients with mild cognitive impairment (12 men, eight women; mean age, 75.0 years ± 7.6 [standard deviation]) and 20 elderly control subjects (nine men, 11 women; mean age, 71.2 years ± 4.5) underwent functional MR imaging at 4 T during a novel-versus-familiar face-name encoding-retrieval task. The magnitude of blood oxygen level–dependent brain responses across the entire brain were compared within and between subjects with mild cognitive impairment and control subjects by using a voxelwise random-effects model. A one-sample t test was used for within-group analysis; an analysis-of-covariance model (with age as a covariate) was used for between-group analysis.

Results: Brain regions activated by the task (prefrontal, medial temporal, and parietal regions) during encoding were similar to those activated during retrieval, with larger areas activated during retrieval. Subjects with mild cognitive impairment showed decreased magnitude of activation in bilateral frontal cortex regions (during encoding and retrieval), the left hippocampus (during retrieval), and the left cerebellum (during encoding) compared with magnitude of activation in control subjects (P < .001). Patients with mild cognitive impairment showed increased activation in the posterior frontal lobes (during retrieval) (P < .001). Lower hippocampal activation during retrieval was the most significant correlate of clinical severity of memory loss in mild cognitive impairment (P < .001).

Conclusion: A difference exists in the response of brain regions underlying encoding and retrieval in mild cognitive impairment. Memory deficits in mild cognitive impairment may be linked to functional alterations in several specific brain regions both inside and outside the medial temporal lobe.

© RSNA, 2006




This article has been cited by other articles:


Home page
 AJGPHome page
A. L. Jefferson, L. K. Byerly, S. Vanderhill, S. Lambe, S. Wong, A. Ozonoff, and J. H. Karlawish
Characterization of Activities of Daily Living in Individuals With Mild Cognitive Impairment
Am J Geriatr Psychiatry, May 1, 2008; 16(5): 375 - 383.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. Xu, P. G. Antuono, J. Jones, Y. Xu, G. Wu, D. Ward, and S. -J. Li
Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects
Neurology, October 23, 2007; 69(17): 1650 - 1656.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. R. Petrella, L. Wang, S. Krishnan, M. J. Slavin, S. E. Prince, T.-T. T. Tran, and P. M. Doraiswamy
Cortical Deactivation in Mild Cognitive Impairment: High-Field-Strength Functional MR Imaging
Radiology, October 1, 2007; 245(1): 224 - 235.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. E. Smith, V. S. Pankratz, S. Negash, M. M. Machulda, R. C. Petersen, B. F. Boeve, D. S. Knopman, J. A. Lucas, T. J. Ferman, N. Graff-Radford, et al.
A plateau in pre-Alzheimer memory decline: Evidence for compensatory mechanisms?
Neurology, July 10, 2007; 69(2): 133 - 139.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
R. SPERLING
Functional MRI Studies of Associative Encoding in Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease
Ann. N.Y. Acad. Sci., February 1, 2007; 1097(1): 146 - 155.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2006 by the Radiological Society of North America.