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Quantification of Lung Tumor Volume and Rotation at 3D Dynamic Parallel MR Imaging with View Sharing: Preliminary Results¹

¹ From the Departments of Radiology (C.P., C.F., H.U.K.) and Medical and Biological Informatics (M.S., H.P.M.), German Cancer Research Center, Heidelberg, Germany; Department of Diagnostic Radiology, Eberhard-Karls University, Hoppe-Seyler 3, 72076 Tuebingen, Germany (C.P.); Department of Diagnostic Radiology, Ludwig Maximilian University, Munich, Germany (C.F.); and Department of Radiation Therapy, University of Heidelberg, Heidelberg, Germany (H.H., J.D.). Received May 2, 2005; revision requested June 23; revision received June 30; accepted August 2; final version accepted September 14. Address correspondence to C.P. (e-mail: c.plathow{at}dkfz.de, christian.plathow{at}med.uni-tuebingen.de).

The purpose of this study was to prospectively evaluate the volumes and rotations of pulmonary nodules during respiration by using three-dimensional fast low-angle shot dynamic magnetic resonance (MR) imaging (1.5/0.6 [repetition time msec/echo time msec], 3.8 x 3.8 x 3.8-mm voxel size, imaging time per three-dimensional data set of 1 second). The feasibility of the technique was verified by using 130-, 40-, and 12-cm³ phantoms made of meatballs and in five patients with solitary intrapulmonary tumors (four men, one woman; median age, 60 years) at computed tomography and histologic analysis. All patients provided written informed consent, and the study was institutional review board approved. It was proved that there were no substantial differences among the 21 algorithms used to correct partial volume effects. The most precise algorithm (r > 0.9, P < .01) used to correct partial volume effects—with which mean phantom volumes of 120.8 cm³ ± 4.1, 36.1 cm³ ± 3.98, and 13.1 cm³ ± 1.5 were calculated—yielded a root mean square error of 14%. The MR imaging–derived nodule volume and rotation during respiration could be quantified by using oriented bounding box techniques.

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