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Automated Hepatic Volumetry for Living Related Liver Transplantation At Multisection CT¹

¹ From the Departments of Diagnostic Radiology (Y.N., K.A., S. Kusunoki, Y.Y.) and Transplantation/Pediatric Surgery (H.O., Y.I.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto City, Kumamoto, 860-8556, Japan; Department of Radiology, the Kurt Rossmann Laboratories for Radiologic Image Research, University of Chicago, Chicago, Ill (Q.L., K.D.); Department of Radiological Technology, School of Health Sciences, Kumamoto University, Kumamoto, Japan (S. Katsuragawa); Department of Radiology, Kumamoto University Hospital, Kumamoto, Japan (R.I., Y.H.). Received May 19, 2005; revision requested July 18; revision received September 4; accepted September 23; final version accepted, November 14. Supported in part by USPHS grants CA 62625 and CA 64370. Address correspondence to Y.N. (e-mail: yosiharu156{at}lily.ocn.ne.jp).

Purpose: To prospectively compare in vivo hepatic automated volumetry with manual volumetry and measured liver volume.

Materials and Methods: The study was conducted in accordance with the guidelines of the Institutional Review Board of Kumamoto University (Japan). Patient informed consent was obtained. Preoperative multisection computed tomography (CT) was performed in 35 consecutive patients (21 men, 14 women; mean age, 42.8 years; range, 28–72 years) with hepatic disease awaiting living related liver transplantation. The CT scans covered the entire liver at a section thickness of 2.5 mm. Liver volume was estimated by using both the automated and the manual methods. Actual liver weight was obtained for all patients and was converted to hepatic volume on the basis of a predetermined relationship between actual liver weight and volume. Processing time required for both methods was also recorded. Two-tailed paired t test, correlation coefficient, and Bland-Altman tests were used for statistical analyses.

Results: Mean liver weight was 881.7 g ± 249.8 (standard deviation), and mean measured liver volume was 956.00 cm³ ± 280.10. Volumetry performed with the automated and manual methods provided liver volumes of 982.99 cm³ ± 301.98 and 937.10 cm³ ± 301.31, respectively. There was good correlation between measured and estimated volumes obtained with the automated method (r = 0.792, P < .01). The manual and automated methods required 32.8 minutes ± 6.9 and 4.4 minutes ± 1.9, respectively.

Conclusion: The automated method reduced the time required for volumetry of the liver and provided acceptable measurements.

© RSNA, 2006