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Gallstone Detection at CT in Vitro: Effect of Peak Voltage Setting¹

¹ From the Departments of Radiology (W.C.C., B.M.Y., F.V.C., R.G.G., S.P., W.C.B., A.Q., B.N.J.) and Surgery (K.S.K.), University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628 and the Laboratory for Stone Research (E.L.P.), Waban, Mass. Received June 8, 2005; revision requested August 2; revision received September 29; accepted October 14; final version accepted January 9, 2006. Address correspondence to B.M.Y. (e-mail: ben.yeh{at}radiology.ucsf.edu).

This study was a retrospective single-institutional study approved by the Committee on Human Research and was HIPAA compliant. A waiver for informed consent was granted. The purpose of the study was to evaluate the effect of four peak voltage settings on the in vitro conspicuity of gallstones in an anthropomorphic phantom at computed tomography (CT). An anthropomorphic phantom was scanned with (n = 86) or without (n = 85) gallstones at CT by using 80, 100, 120, and 140 kVp. The sensitivity for gallstone detection was significantly higher at 140 kVp (86% [74 of 86] for reader 1 and 81% [70 of 86] for reader 2) than at lower voltage settings (up to 67% [58 of 86] for reader 1 and 63% [54 of 86] for reader 2, P < .05 for each reader), regardless of gallstone size (<1.0 cm vs 1.0 cm in diameter, P < .05 for each reader). CT attenuation measurements were not useful for determination of gallstone composition. Abdominal CT performed at 140 kVp may be useful when gallstone disease is of clinical concern.

© RSNA, 2006

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