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High-Spatial-Resolution Multistation MR Angiography with Parallel Imaging and Blood Pool Contrast Agent: Initial Experience¹

¹ From the Department of Clinical Radiology, Ludwig-Maximilians University of Munich, Grosshadern Campus, Marchioninistr 15, 81377 Munich, Germany (K.N., H.K., C.G., D.C., O.D., M.F.R., S.O.S.); EPIX Pharmaceuticals, Cambridge, Mass (M.H., P.C.); and Siemens Medical Solutions, Erlangen, Germany (S.A.). Received January 11, 2006; revision requested March 9; revision received April 13; accepted May 17; final version accepted June 16. Supported by EPIX Pharmaceuticals. Address correspondence to K.N. (e-mail: Konstantin.Nikolaou{at}med.uni-muenchen.de).

The purpose of this study was to prospectively evaluate the diagnostic accuracy of reader detection of 75% or greater stenosis at high-spatial-resolution multistation magnetic resonance (MR) angiography performed with matrix coils and a blood pool contrast agent. Ten healthy volunteers and 10 patients were examined. All participants provided informed consent to participate in this institutional review board–approved study. For contrast agent–enhanced multistation MR angiography, an albumin-binding gadolinium chelate, gadofosveset trisodium, was used. Imaging was performed during the first-pass and steady-state phases of the contrast agent. Vessel conspicuity on the first-pass MR angiograms obtained in both volunteers and patients was rated as excellent for 93% of vessels. At steady-state imaging, vessel conspicuity was rated as excellent or good for 89% of vessels. Gadofosveset trisodium–enhanced MR angiography yielded sensitivities of 100% and 97% and specificities of 96% and 97% for detection of significant disease in the carotid and lower extremity arteries, respectively.

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© RSNA, 2006

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