HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2423060299v1 242/3/735    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cheng, A. S. H. Articles by Selvanayagam, J. B. Search for Related Content PubMed PubMed Citation Articles by Cheng, A. S. H. Articles by Selvanayagam, J. B.

Irreversible Myocardial Injury: Assessment with Cardiovascular Delayed-Enhancement MR Imaging and Comparison of 1.5 and 3.0 T—Initial Experience¹

¹ From the University of Oxford Centre for Clinical Magnetic Resonance Research and Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, England. Received February 16, 2006; revision requested April 20; revision received May 15; final version accepted July 7. Supported by grants from the British Heart Foundation and Medical Research Council. A.S.H.C. supported by a grant from the Oxfordshire Health Services Research Committee. J.B.S. supported by an intermediate research fellowship from the British Heart Foundation. Address correspondence to J.B.S. (e-mail: joseph.selvanayagam{at}cardiov.ox.ac.uk).

Purpose: To prospectively compare visualization and quantification of irreversible myocardial injury in patients with chronic myocardial infarction at 1.5- and 3.0-T magnetic resonance (MR) imaging.

Materials and Methods: The institutional research ethics committee approved the study. Participants gave written informed consent. Sixteen male patients (mean age, 66 years ± 13 [standard deviation]) with myocardial infarction were imaged with the same sequence by the same operator at 1.5 and 3.0 T. After cine imaging, a bolus of gadodiamide was administered. Short-axis images of entire left ventricle (LV) were acquired with a breath-hold T1-weighted segmented inversion-recovery turbo fast low-angle shot (FLASH) sequence. Agreement for myocardial hyperenhancement (HE) mass between field strengths was assessed with Bland-Altman method; agreement for detection and transmural extent of HE was assessed with statistics. Intra- and interobserver reproducibility of mass and transmural extent of HE were assessed at 1.5 and 3.0 T.

Results: Bland-Altman analysis revealed no systematic bias (mean difference, 0.2 g; 95% confidence interval: –0.7 g, 1.2 g) and acceptable limits of agreement (–3.3 to 3.8 g) between field strengths for HE mass. HE mass measurements were strongly correlated (R² = 0.99); there was no significant difference in measurements at 1.5 and 3.0 T (28.1 g ± 15.7 [22.6% ± 10.9 of LV mass] vs 27.8 g ± 15.7 [22.3% ± 10.7 of LV mass], respectively; P = .599). For all segments, there was a high degree of agreement for HE detection ( = 0.90) and transmural grade ( = 0.79) between field strengths. Intra- and interobserver variability were low between both field strengths. Initial inversion time selected to null the signal of normal myocardium at 3.0 T was 57 msec ± 20 longer than at 1.5 T (P < .01).

Conclusion: By using the same turbo FLASH MR pulse sequence, there was strong agreement in mass and transmural extent of myocardial HE between 1.5 and 3.0 T.

© RSNA, 2007

This article has been cited by other articles:

				C. K. Kuhl, F. Traber, J. Gieseke, W. Drahanowsky, N. Morakkabati-Spitz, W. Willinek, M. von Falkenhausen, C. Manka, and H. H. Schild Whole-Body High-Field-Strength (3.0-T) MR Imaging in Clinical Practice * Part II. Technical Considerations and Clinical Applications Radiology, April 1, 2008; 247(1): 16 - 35. [Abstract] [Full Text] [PDF]

				A. S.H. Cheng, J. B. Selvanayagam, M. Jerosch-Herold, W. J. van Gaal, T. D. Karamitsos, S. Neubauer, and A. P. Banning Percutaneous Treatment of Chronic Total Coronary Occlusions Improves Regional Hyperemic Myocardial Blood Flow and Contractility: Insights From Quantitative Cardiovascular Magnetic Resonance Imaging J. Am. Coll. Cardiol. Intv., February 1, 2008; 1(1): 44 - 53. [Abstract] [Full Text] [PDF]

				A. S.H. Cheng, T. J. Pegg, T. D. Karamitsos, N. Searle, M. Jerosch-Herold, R. P. Choudhury, A. P. Banning, S. Neubauer, M. D. Robson, and J. B. Selvanayagam Cardiovascular Magnetic Resonance Perfusion Imaging at 3-Tesla for the Detection of Coronary Artery Disease: A Comparison With 1.5-Tesla J. Am. Coll. Cardiol., June 26, 2007; 49(25): 2440 - 2449. [Abstract] [Full Text] [PDF]