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Published online before print January 23, 2007, 10.1148/radiol.2423060196
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(Radiology 2007;242:898-906.)
© RSNA, 2007


Thoracic Imaging

Air Trapping: Comparison of Standard-Dose and Simulated Low-Dose Thin-Section CT Techniques1

Alexander A. Bankier, MD, Cornelia Schaefer-Prokop, MD, Viviane De Maertelaer, PhD, Denis Tack, MD, PhD, Peter Jaksch, MD, Walter Klepetko, MD and Pierre Alain Gevenois, MD, PhD

1 From the Department of Radiology (A.A.B.) and Department of Cardio-Thoracic Surgery, Lung Transplantation Unit (P.J., W.K.), Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; Department of Radiology, University of Amsterdam, Amsterdam, the Netherlands (C.S.); Statistical Unit, Institute of Interdisciplinary Research in Human and Molecular Biology (V.D.M.), and Department of Radiology, University Erasme Hospital (P.A.G.), Université Libre de Bruxelles, Brussels, Belgium; and Department of Radiology, RHMS Clinic Louis Caty, Baudour, Belgium (D.T.). Received February 1, 2006; revision requested March 29; revision received April 6; final version accepted June 1. Address correspondence to A.A.B. (e-mail: alexander.bankier{at}meduniwien.ac.at).

Purpose: To prospectively investigate the effect of radiation dose reduction on the visual quantification of air trapping at expiratory thin-section computed tomography (CT).

Materials and Methods: In this ethical committee–approved study, 27 lung transplant recipients (12 women, 15 men; mean age, 54 years ± 2 [standard error of the mean]) underwent expiratory thin-section CT at 140 kVp and 80 mAs (effective). All patients gave written informed consent. Dose reduction corresponding to 60, 40, and 20 mAs (effective) was simulated. The extent of air trapping in both original and dose-reduced studies was scored by three independent readers. The effects of tube current–time product, reader, reading session, and body mass index on average air trapping scores were assessed with analysis of variance. Agreements between and within observers were assessed with a weighted {kappa} statistic. Subjective scores for diagnostic confidence were attributed (3 = high, 2 = medium, 1 = low), and their means were calculated for each tube current–time product value.

Results: No significant effect on average air trapping scores as a result of tube current–time product (P = .222), reader (P = .217), reading session (P = .705), or body mass index (P = .505) could be detected. At 80 mAs, agreement between readers was excellent; agreement decreased to good or moderate at lower tube current settings. Agreement within readers decreased with a decrease in dose but remained good even at 20 mAs. Confidence also decreased, with mean scores decreasing from 2.33 ± 0.73 (standard deviation) to 1.04 ± 0.19 when dose decreased.

Conclusion: At 140 kVp, the tube current–time product can be reduced from 80 to 20 mAs without impairing the visual quantification of air trapping at expiratory thin-section CT and with acceptable decreases in agreement between and within readers and in reader confidence.

© RSNA, 2007




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