Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print January 31, 2007, 10.1148/radiol.2431062144
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2431062144v1
243/1/148    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sadowski, E. A.
Right arrow Articles by Djamali, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sadowski, E. A.
Right arrow Articles by Djamali, A.
(Radiology 2007;243:148-157.)
© RSNA, 2007

Genitourinary Imaging

Nephrogenic Systemic Fibrosis: Risk Factors and Incidence Estimation1

Elizabeth A. Sadowski, MD, Lindsey K. Bennett, MD, Micah R. Chan, MD, Andrew L. Wentland, BS, Andrea L. Garrett, MD, Robert W. Garrett, MD and Arjang Djamali, MD

1 From the Departments of Radiology (E.A.S., R.W.G.), Dermatology (L.K.B., A.L.G.), Medicine (M.R.C., A.D.), and Biophysics (A.L.W.), University of Wisconsin, 600 Highland Ave, Madison, WI 53792-3252. Received December 15, 2006; revision requested January 3, 2007; revision received January 10; final version accepted January 11. Address correspondence to E.A.S. (e-mail: esadowski{at}uwhealth.org).

Purpose: To retrospectively review data in 13 patients with biopsy-confirmed nephrogenic systemic fibrosis (NSF), assess the associated risk factors, and report the incidence of NSF at the authors' institution.

Materials and Methods: This HIPAA-compliant study had institutional review board approval; informed consent was waived. Statistical analysis was performed for all available clinical and laboratory data in patients with biopsy-confirmed NSF. The data from the patients with NSF were compared with data from a control population of patients with renal insufficiency but who did not develop NSF.

Results: There were eight male and five female patients, aged 17–69 years, with a diagnosis of NSF. Within 6 months of diagnosis, all 13 patients had been exposed to gadodiamide and one had been exposed to gadobenate dimeglumine in addition to gadodiamide. At the time of contrast material–enhanced magnetic resonance (MR) imaging, all 13 patients had renal insufficiency (estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m2) and were hospitalized for a proinflammatory event (major surgery, infection, or vascular event). The group with NSF had significantly decreased eGFR (P = .01), more proinflammatory events (P < .001), and more contrast-enhanced MR examinations per patient (P = .002) than did the control group.

Conclusion: A combination of factors, including altered kidney function, inflammatory burden, and exposure to gadolinium-based contrast agents may all play a role in development of NSF. Alternative imaging should be considered in patients with these factors. If use of a gadolinium-based agent is clinically indicated, the referring physician and patient should be informed of the potential risk of developing NSF.

© RSNA, 2007




This article has been cited by other articles:


Home page
 RadiologyHome page
A. Tomasian, N. Salamon, D. G. Lohan, M. Jalili, J. P. Villablanca, and J. P. Finn
Supraaortic Arteries: Contrast Material Dose Reduction at 3.0-T High-Spatial-Resolution MR Angiography--Feasibility Study
Radiology, December 1, 2008; 249(3): 980 - 990.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
P. H. Kuo
NSF-Active and NSF-Inert Species of Gadolinium: Mechanistic and Clinical Implications
Am. J. Roentgenol., December 1, 2008; 191(6): 1861 - 1863.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. M. Provenzale
Nephrogenic Systemic Fibrosis: Some Considerations on the Debate Regarding Its Cause
Am. J. Roentgenol., December 1, 2008; 191(6): 1867 - 1869.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
A. G. Bleicher and E. Kanal
Assessment of Adverse Reaction Rates to a Newly Approved MRI Contrast Agent: Review of 23,553 Administrations of Gadobenate Dimeglumine
Am. J. Roentgenol., December 1, 2008; 191(6): W307 - W311.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. Makkat, R. Luypaert, T. Stadnik, C. Bourgain, S. Sourbron, M. Dujardin, J. De Greve, and J. De Mey
Deconvolution-based Dynamic Contrast-enhanced MR Imaging of Breast Tumors: Correlation of Tumor Blood Flow with Human Epidermal Growth Factor Receptor 2 Status and Clinicopathologic Findings--Preliminary Results
Radiology, November 1, 2008; 249(2): 471 - 482.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
R. Agarwal, S. M. Brunelli, K. Williams, M. D. Mitchell, H. I. Feldman, and C. A. Umscheid
Gadolinium-based contrast agents and nephrogenic systemic fibrosis: a systematic review and meta-analysis
Nephrol. Dial. Transplant., October 24, 2008; (2008) gfn593v1.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. C. Weinreb
Which Study When? Is Gadolinium-enhanced MR Imaging Safer than Iodine-enhanced CT?
Radiology, October 1, 2008; 249(1): 3 - 8.
[Full Text] [PDF]

Home page
 RadiologyHome page
R. A. Halvorsen
Which Study When? Iodinated Contrast-enhanced CT Versus Gadolinium-enhanced MR Imaging
Radiology, October 1, 2008; 249(1): 9 - 15.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
F. G. Shellock and A. Spinazzi
MRI Safety Update 2008: Part 1, MRI Contrast Agents and Nephrogenic Systemic Fibrosis
Am. J. Roentgenol., October 1, 2008; 191(4): 1129 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
P. M. Colletti
Nephrogenic Systemic Fibrosis and Gadolinium: A Perfect Storm
Am. J. Roentgenol., October 1, 2008; 191(4): 1150 - 1153.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
L. E. M. Duijm, E. H. Overbosch, Y. S. Liem, R. N. Planken, J. H. M. Tordoir, P. W. M. Cuypers, P. Douwes-Draaijer, and M. W. de Haan
Retrograde catheterization of haemodialysis fistulae and grafts: angiographic depiction of the entire vascular access tree and stenosis treatment
Nephrol. Dial. Transplant., September 18, 2008; (2008) gfn526v1.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
S. G. Yarlagadda, S. G. Coca, A. X. Garg, M. Doshi, E. Poggio, R. J. Marcus, and C. R. Parikh
Marked variation in the definition and diagnosis of delayed graft function: a systematic review
Nephrol. Dial. Transplant., September 1, 2008; 23(9): 2995 - 3003.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. R. Prince, H. Zhang, M. Morris, J. L. MacGregor, M. E. Grossman, J. Silberzweig, R. L. DeLapaz, H. J. Lee, C. M. Magro, and A. M. Valeri
Incidence of Nephrogenic Systemic Fibrosis at Two Large Medical Centers
Radiology, September 1, 2008; 248(3): 807 - 816.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. de Bazelaire, D. C. Alsop, D. George, I. Pedrosa, Y. Wang, M. D. Michaelson, and N. M. Rofsky
Magnetic Resonance Imaging-Measured Blood Flow Change after Antiangiogenic Therapy with PTK787/ZK 222584 Correlates with Clinical Outcome in Metastatic Renal Cell Carcinoma
Clin. Cancer Res., September 1, 2008; 14(17): 5548 - 5554.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. S. Jaffe
Key Issues in the Developing Synergism between Cardiovascular Imaging and Biomarkers
Clin. Chem., September 1, 2008; 54(9): 1432 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
R. Wertman, , BA, E. Altun, D. R. Martin, D. G. Mitchell, J. R. Leyendecker, R. B. O'Malley, D. J. Parsons, E. R. Fuller III, and R. C. Semelka
Risk of Nephrogenic Systemic Fibrosis: Evaluation of Gadolinium Chelate Contrast Agents at Four American Universities
Radiology, September 1, 2008; 248(3): 799 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A.R. Deibler, J.M. Pollock, R.A. Kraft, H. Tan, J.H. Burdette, and J.A. Maldjian
Arterial Spin-Labeling in Routine Clinical Practice, Part 1: Technique and Artifacts
AJNR Am. J. Neuroradiol., August 1, 2008; 29(7): 1228 - 1234.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
R. Habibi, M. S. Krishnam, D. G. Lohan, F. Barkhordarian, M. Jalili, R. S. Saleh, S. G. Ruehm, and J. P. Finn
High-Spatial-Resolution Lower Extremity MR Angiography at 3.0 T: Contrast Agent Dose Comparison Study
Radiology, August 1, 2008; 248(2): 680 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
J. Wang, V. L. Yarnykh, J. A. Molitor, R. A. Nash, B. Chu, G. J. Wilson, J. Fleming, S. M. Schwartz, and C. Yuan
Micro magnetic resonance angiography of the finger in systemic sclerosis
Rheumatology, August 1, 2008; 47(8): 1239 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
B. J. Schietinger, G. M. Brammer, H. Wang, J. M. Christopher, K. W. Kwon, A. J. Mangrum, J. M. Mangrum, and C. M. Kramer
Patterns of Late Gadolinium Enhancement in Chronic Hemodialysis Patients
J. Am. Coll. Cardiol. Img., July 1, 2008; 1(4): 450 - 456.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
N. M. Rofsky
Nephrogenic Systemic Fibrosis: Considerations for the Cardiologist
J. Am. Coll. Cardiol. Img., July 1, 2008; 1(4): 457 - 459.
[Full Text] [PDF]

Home page
 RadiologyHome page
M. Miyazaki and V. S. Lee
Nonenhanced MR Angiography
Radiology, July 1, 2008; 248(1): 20 - 43.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
N. M. Rofsky, A. D. Sherry, and R. E. Lenkinski
Nephrogenic Systemic Fibrosis: A Chemical Perspective
Radiology, June 1, 2008; 247(3): 608 - 612.
[Full Text] [PDF]

Home page
 CJASNHome page
R. F. Reilly
Risk for Nephrogenic Systemic Fibrosis with Gadoteridol (ProHance) in Patients Who Are on Long-Term Hemodialysis
Clin. J. Am. Soc. Nephrol., May 1, 2008; 3(3): 747 - 751.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
C. Y. Kim, R. A. Mirza, J. A. Bryant, E. D. Whiting, D. M. Delong, C. E. Spritzer, and E. M. Merkle
Central Veins of the Chest: Evaluation with Time-resolved MR Angiography
Radiology, May 1, 2008; 247(2): 558 - 566.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Becker, A. Lenzen, C. Ocklenburg, K. Stempel, H. Kuhl, M. Neizel, M. Katoh, R. Kramann, J. Wildberger, M. Kelm, et al.
Myocardial Deformation Imaging Based on Ultrasonic Pixel Tracking to Identify Reversible Myocardial Dysfunction
J. Am. Coll. Cardiol., April 15, 2008; 51(15): 1473 - 1481.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
C. J. Francois, D. Tuite, V. Deshpande, R. Jerecic, P. Weale, and J. C. Carr
Unenhanced MR Angiography of the Thoracic Aorta: Initial Clinical Evaluation
Am. J. Roentgenol., April 1, 2008; 190(4): 902 - 906.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
C. D. Wiginton, B. Kelly, A. Oto, M. Jesse, P. Aristimuno, R. Ernst, and G. Chaljub
Gadolinium-Based Contrast Exposure, Nephrogenic Systemic Fibrosis, and Gadolinium Detection in Tissue
Am. J. Roentgenol., April 1, 2008; 190(4): 1060 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
L. P. Golding and J. M. Provenzale
Nephrogenic Systemic Fibrosis: Possible Association with a Predisposing Infection
Am. J. Roentgenol., April 1, 2008; 190(4): 1069 - 1075.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
G. Soulez, M. Pasowicz, G. Benea, L. Grazioli, J. P. Niedmann, M. Konopka, P. C. Douek, G. Morana, F. K. W. Schaefer, A. Vanzulli, et al.
Renal Artery Stenosis Evaluation: Diagnostic Performance of Gadobenate Dimeglumine-enhanced MR Angiography--Comparison with DSA
Radiology, April 1, 2008; 247(1): 273 - 285.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. Vogelsberg, H. Mahrholdt, C. C. Deluigi, A. Yilmaz, E. M. Kispert, S. Greulich, K. Klingel, R. Kandolf, and U. Sechtem
Cardiovascular magnetic resonance in clinically suspected cardiac amyloidosis: noninvasive imaging compared to endomyocardial biopsy.
J. Am. Coll. Cardiol., March 11, 2008; 51(10): 1022 - 1030.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
W. M. Shabana, R. H. Cohan, J. H. Ellis, H. K. Hussain, I. R. Francis, L. D. Su, S. K. Mukherji, and R. D. Swartz
Nephrogenic Systemic Fibrosis: A Report of 29 Cases
Am. J. Roentgenol., March 1, 2008; 190(3): 736 - 741.
[Abstract] [Full Text] [PDF]

Home page
 Cleveland Clinic Journal of MedicineHome page
N. ISSA, E. D. POGGIO, R. A. FATICA, R. PATEL, P. M. RUGGIERI, and R. J. HEYKA
Nephrogenic systemic fibrosis and its association with gadolinium exposure during MRI
Cleveland Clinic Journal of Medicine, February 1, 2008; 75(2): 95 - 111.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
E. Giannitsis, H. Steen, K. Kurz, B. Ivandic, A. C. Simon, S. Futterer, C. Schild, P. Isfort, A. S. Jaffe, and H. A. Katus
Cardiac Magnetic Resonance Imaging Study for Quantification of Infarct Size Comparing Directly Serial Versus Single Time-Point Measurements of Cardiac Troponin T
J. Am. Coll. Cardiol., January 22, 2008; 51(3): 307 - 314.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
A. Kahana, M. J. Lucarelli, A. M. Grayev, J. J. Van Buren, C. N. Burkat, and L. R. Gentry
Noninvasive Dynamic Magnetic Resonance Angiography With Time-Resolved Imaging of Contrast KineticS (TRICKS) in the Evaluation of Orbital Vascular Lesions
Arch Ophthalmol, December 1, 2007; 125(12): 1635 - 1642.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
E. Kanal, D. R. Broome, D. R. Martin, and H. S. Thomsen
Response to the FDA's May 23, 2007, Nephrogenic Systemic Fibrosis Update
Radiology, December 1, 2007; 246(1): 11 - 14.
[Full Text] [PDF]

Home page
 RadiologyHome page
G. Korosoglou, W. D. Gilson, M. Schar, A. Ustun, L. V. Hofmann, D. L. Kraitchman, and M. Stuber
Hind Limb Ischemia in Rabbit Model: T2-prepared versus Time-of-Flight MR Angiography at 3 T
Radiology, December 1, 2007; 245(3): 761 - 769.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. S.B. Beanlands, G. Nichol, E. Huszti, D. Humen, N. Racine, M. Freeman, K. Y. Gulenchyn, L. Garrard, R. deKemp, A. Guo, et al.
F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients With Severe Left Ventricular Dysfunction and Suspected Coronary Disease: A Randomized, Controlled Trial (PARR-2)
J. Am. Coll. Cardiol., November 13, 2007; 50(20): 2002 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
P. Marckmann, L. Skov, K. Rossen, J. G. Heaf, and H. S. Thomsen
Case-control study of gadodiamide-related nephrogenic systemic fibrosis
Nephrol. Dial. Transplant., November 1, 2007; 22(11): 3174 - 3178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S. Thurnher, S. Miller, G. Schneider, C. Ballarati, G. Bongartz, C. U. Herborn, S. Schoenberg, M. A. Cova, G. Morana, K. Niazi, et al.
Diagnostic Performance of Gadobenate Dimeglumine Enhanced MR Angiography of the Iliofemoral and Calf Arteries: A Large-Scale Multicenter Trial
Am. J. Roentgenol., November 1, 2007; 189(5): 1223 - 1237.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. A. Collidge, P. C. Thomson, P. B. Mark, J. P. Traynor, A. G. Jardine, S. T. W. Morris, K. Simpson, and G. H. Roditi
Gadolinium-enhanced MR Imaging and Nephrogenic Systemic Fibrosis: Retrospective Study of a Renal Replacement Therapy Cohort
Radiology, October 1, 2007; 245(1): 168 - 175.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Swaminathan and S. V. Shah
New Insights into Nephrogenic Systemic Fibrosis
J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2636 - 2643.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
G. Saab, A. Abu-Alfa, E. A. Sadowski, and A. Djamali
Are Patients with Moderate Renal Failure at Risk for Developing Nephrogenic Systemic Fibrosis?
Radiology, September 1, 2007; 244(3): 930 - 932.
[Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
A. S Peak and A. Sheller
Risk Factors for Developing Gadolinium-Induced Nephrogenic Systemic Fibrosis
Ann. Pharmacother., September 1, 2007; 41(9): 1481 - 1485.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2007 by the Radiological Society of North America.