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Nano- and Microparticle-based Imaging of Cardiovascular Interventions: Overview¹

¹ From the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md; and Department of Radiology, Image-Guided Bio-Molecular Interventions Research, University of Washington, 1959 NE Pacific St, HSC AA-036, Box 357987, Seattle, WA 98195-7987. Supported by National Institutes of Health grant R01 HL078672. Received February 16, 2006; revision requested April 20; revision received May 2; accepted June 1; final version accepted August 14; final review by author November 14. Address correspondence to the author (e-mail: xmyang{at}u.washington.edu).

The rapid progress of nanoscience and the application of nanotechnology are changing the foundations of diagnosis, treatment, and prevention of cardiovascular diseases. As the core of nanotechnology, nano- and microparticles offer "three-in-one" functions as imaging agents, target probes, and therapeutic carriers. While nano- and microparticle-based imaging of cardiovascular interventions is still in its developing phase, it has already presented the exciting potential to monitor primary interventional procedures for precise therapeutic delivery, enhance the effectiveness of delivered therapeutics, and monitor therapeutic efficiency after interventions performed to treat cardiovascular diseases. This article provides an overview of the current status of the application of nano- and microparticles in the imaging of cardiovascular interventions.

© RSNA, 2007