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Diagnostic Accuracy of Image Postprocessing Methods for the Detection of Coronary Artery Stenoses by Using Multidetector CT¹

¹ From the Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (M.F., S.A., R.C.C., U.H., K.N., T.J.B., F.M., S.A.); and Department of Internal Medicine II, University of Erlangen, Ulmenweg 18, Erlangen 91054, Germany (D.R., W.G.D., S.A.). Received January 15, 2006; revision requested March 14; revision received May 24; accepted June 8; final version accepted October 4. Supported in part by Staedtler-Foundation, Nuremberg, Germany. M.F. supported in part by National Institutes of Health grant 1 T32 HL076136-02. K.N. supported by Interuniversity Cardiology Institute of the Netherlands (Utrecht, the Netherlands). F.M. supported by Daniela und Juergen Westphal-Stiftung, Flensburg, Germany. Address correspondence to S.A. (e-mail: stephan.achenbach{at}med2.med.uni-erlangen.de).

Purpose: To retrospectively evaluate the diagnostic accuracy of multidetector computed tomography (CT) coronary angiography for detection of hemodynamically significant (50%) stenoses by using various image postprocessing methods, with conventional coronary angiography as the reference standard.

Materials and Methods: The analysis used data from previous studies, use of which had been approved by the Institutional Review Board. Sixteen-section multidetector CT data sets for 40 patients (30 men, 10 women; mean age 56 years ± 8; mean heart rate, 61 beats per minute ± 6) were evaluated. Six independent investigators evaluated the data sets for the presence of stenoses with diameter reduction of 50% or more, by using either exclusively transverse images, free oblique multiplanar reconstructions (MPRs), free oblique maximum intensity projections (MIPs, 5 mm thick), prerendered curved MPRs, prerendered curved MIPs, or prerendered three-dimensional volume rendered reconstructions (VRTs). Evaluation results were compared with conventional coronary angiography for each artery in a blinded fashion (² test).

Results: Overall, 35 coronary artery stenoses were present. Percentage of evaluable arteries and accuracy for detecting stenosis (percentages of accurately classified arteries were, respectively, 99% and 88% for transverse, 99% and 91% for oblique MPR, 94% and 86% for oblique MIP, 94% and 83% for curved MIP, 93% and 81% for curved MPR, and 91% and 73% for VRT). Accuracy was significantly higher for oblique MPR than for curved MPR (P = .01), curved MIP (P = .03), and VRT (P < .001).

Conclusion: The evaluation of multidetector CT coronary angiography with interactive image display methods, especially interactive oblique MPRs, permits higher diagnostic accuracy than evaluation of prerendered images (curved MPR, curved MIP, or VRT images).

© RSNA, 2007

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