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DOI: 10.1148/radiol.2441060790
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(Radiology 2007;244:138-143.)
© RSNA, 2007

Experimental Studies

Catheter-directed Gastric Artery Chemical Embolization for Modulation of Systemic Ghrelin Levels in a Porcine Model: Initial Experience1

Aravind Arepally, MD, Brad P. Barnett, BS, Elizabeth Montgomery, MD, and Tarak H. Patel, MD

1 From the Russell H. Morgan Department of Radiology and Radiological Science, Division of Cardiovascular and Interventional Radiology, Johns Hopkins Medical Institutes, Johns Hopkins Hospital, Blalock 545, 600 N Wolfe St, Baltimore, MD 21287. Received May 8, 2006; revision requested July 6; revision received July 26; accepted August 29; final version accepted December 6. Supported by National Institutes of Health grants 1 K08 EB004348-01 and R01 HL61672. Address correspondence to A.A. (e-mail: aarepal{at}jhmi.edu).

Purpose: To prospectively test, in a porcine model, the hypothesis that use of catheter-directed gastric artery chemical embolization (GACE) can result in substantial suppression of systemic ghrelin levels.

Materials and Methods: The institutional animal care and use committee approved this study. Adult healthy swine (40–45 kg, n = 8) were tested. GACE was performed by infusing morrhuate sodium selectively into the left gastric artery. Six swine (animals A–F) underwent left GACE by using a dose-escalating regimen of morrhuate sodium, whereas two control swine underwent a sham procedure. Weight and fasting plasma ghrelin levels were compared in swine at baseline and at weeks 1–4. At week 4, stomachs were excised and analyzed. Analysis of the change in ghrelin values and weight was performed with both paired t test and unpaired Student t test.

Results: In control swine (n = 2), there was no significant difference in ghrelin values before (844.8 pg/mL ± 40 [standard deviation]) and after (997 pg/mL ± 93) the procedure (P = .5). Swine that received a low dose of morrhuate sodium (animals A–D) showed a significant increase in serum ghrelin values from 683.7 pg/mL ± 241 to 1555.9 pg/mL ± 312 (P = .002). At a higher dose, the mean baseline ghrelin values decreased from 466 pg/mL to 187 pg/mL ± 162. Weight changes of +1.4% and +8.6% were seen in swine that underwent GACE and control swine, respectively. Histochemical staining showed preservation of overall tissue architecture and parietal cells.

Conclusion: Use of GACE can result in increased or suppressed ghrelin levels.

© RSNA, 2007


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Erratum
Radiology 2007 245: 922. [Full Text] [PDF]



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A. Arepally, B. P. Barnett, T. T. Patel, V. Howland, R. C. Boston, D. L. Kraitchman, and A. A. Malayeri
Catheter-directed Gastric Artery Chemical Embolization Suppresses Systemic Ghrelin Levels in Porcine Model
Radiology, October 1, 2008; 249(1): 127 - 133.
[Abstract] [Full Text] [PDF]