Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print May 10, 2007, 10.1148/radiol.2433060184
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2433060184v1
244/1/144    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Park, J. K.
Right arrow Articles by Omary, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Park, J. K.
Right arrow Articles by Omary, R. A.
(Radiology 2007;244:144-150.)
© RSNA, 2007

Experimental Studies

Renal Artery Stenosis in Swine: Feasibility of MR Assessment of Renal Function during Percutaneous Transluminal Angioplasty1

Jonathan K. Park, BA, Thomas K. Rhee, MD, Ty A. Cashen, BS, Wanyong Shin, MS, Brian E. Schirf, MD, James A. Gehl, BS, Andrew C. Larson, PhD, Pottumarthi V. Prasad, PhD, Debiao Li, PhD, Timothy J. Carroll, PhD, and Reed A. Omary, MD, MS

1 From the Departments of Radiology (J.K.P., T.K.R., T.A.C., W.S., B.E.S., J.A.G., A.C.L., P.V.P., D.L., T.J.C., R.A.O.) and Biomedical Engineering (T.A.C., W.S., D.L., T.J.C., R.A.O.), Northwestern University Feinberg School of Medicine, 448 E Ontario St, Suite 700, Chicago, IL 60611. Received January 30, 2006; revision requested March 29; revision received June 16; accepted June 23; final version accepted October 25. R.A.O. supported in part by National Institutes of Health grant K08 DK60020. J.K.P. supported in part by Northwestern University Feinberg School of Medicine Summer Student Research Grant. Address correspondence to R.A.O. (e-mail: reed{at}northwestern.edu).

Purpose: To prospectively test—in a swine model of renal artery stenosis (RAS)—the hypothesis that magnetic resonance (MR) imaging can reveal changes in renal function at the time of percutaneous transluminal angioplasty (PTA).

Materials and Methods: In this animal care and use committee–approved study, high-grade unilateral RAS was surgically induced in six pigs. MR imaging at 3.0 T was used for intraprocedural assessment of the anatomic and physiologic changes induced by x-ray–guided PTA. With use of MR imaging, changes in single-kidney glomerular filtration rate, extraction fraction, and renal blood flow were assessed during PTA. The arterial diameter of stenosis before and after PTA was assessed by using conventional digital subtraction angiography. Mean changes in functional and anatomic parameters were compared by using the Wilcoxon signed rank test ({alpha} = .05).

Results: At digital subtraction angiography, the mean percentage of stenosis was 69% ± 10 (standard deviation) before PTA and 26% ± 10 after PTA (P < .03). Mean pre- and post-PTA extraction fraction values were 0.11 ± 0.03 and 0.19 ± 0.06, respectively (P < .03). The mean single-kidney glomerular filtration rate before PTA, 19 mL/min ± 13, increased to 41 mL/min ± 33 after PTA (P < .03). There was no significant change in mean renal blood flow after PTA (P = .44).

Conclusion: In swine, MR imaging can reveal changes in renal function after x-ray–guided PTA for unilateral RAS.

© RSNA, 2007