HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Brace, C. L. Articles by Lee, F. T. Search for Related Content PubMed PubMed Citation Articles by Brace, C. L. Articles by Lee, F. T., Jr

Microwave Ablation with Multiple Simultaneously Powered Small-gauge Triaxial Antennas: Results from an in Vivo Swine Liver Model¹

¹ From the Departments of Radiology (C.L.B., L.A.S., T.M.F., F.T.L.), Biomedical Engineering (P.F.L.), and Electrical and Computer Engineering (D.W.v.d.W.), University of Wisconsin–Madison, 600 Highland Ave, Madison, WI 53792-3252. Received December 16, 2005; revision requested February 10; revision received September 20; accepted November 3; final version accepted November 8. Supported by National Institutes of Health Grant R21 RR018303-01. Address correspondence to C.L.B. (e-mail: clbrace{at}wisc.edu).

Purpose: To prospectively investigate the ability of a single generator to power multiple small-diameter antennas and create large zones of ablation in an in vivo swine liver model.

Materials and Methods: Thirteen female domestic swine (mean weight, 70 kg) were used for the study as approved by the animal care and use committee. A single generator was used to simultaneously power three triaxial antennas at 55 W per antenna for 10 minutes in three groups: a control group where antennas were spaced to eliminate ablation zone overlap (n = 6; 18 individual zones of ablation) and experimental groups where antennas were spaced 2.5 cm (n = 7) or 3.0 cm (n = 5) apart. Animals were euthanized after ablation, and ablation zones were sectioned and measured. A mixed linear model was used to test for differences in size and circularity among groups.

Results: Mean (±standard deviation) cross-sectional areas of multiple-antenna zones of ablation at 2.5- and 3.0-cm spacing (26.6 cm² ± 9.7 and 32.2 cm² ± 8.1, respectively) were significantly larger than individual ablation zones created with single antennas (6.76 cm² ± 2.8, P < .001) and were 31% (2.5-cm spacing group: multiple antenna mean area, 26.6 cm²; 3x single antenna mean area, 20.28 cm²) to 59% (3.0-cm spacing group: multiple antenna mean area, 32.2 cm²; 3x single antenna mean area, 20.28 cm²) larger than 3 times the mean area of the single-antenna zones. Zones of ablation were found to be very circular, and vessels as large as 1.1 cm were completely coagulated with multiple antennas.

Conclusion: A single generator may effectively deliver microwave power to multiple antennas. Large volumes of tissue may be ablated and large vessels coagulated with multiple-antenna ablation in the same time as single-antenna ablation.

© RSNA, 2007

This article has been cited by other articles:

				C. L. Brace, J. L. Hinshaw, P. F. Laeseke, L. A. Sampson, and F. T. Lee Jr Pulmonary Thermal Ablation: Comparison of Radiofrequency and Microwave Devices by Using Gross Pathologic and CT Findings in a Swine Model Radiology, June 1, 2009; 251(3): 705 - 711. [Abstract] [Full Text] [PDF]

				N. A. Durick, P. F. Laeseke, L. S. Broderick, F. T. Lee Jr, L. A. Sampson, T. M. Frey, T. F. Warner, J. P. Fine, D. W. van der Weide, and C. L. Brace Microwave Ablation with Triaxial Antennas Tuned for Lung: Results in an in Vivo Porcine Model Radiology, April 1, 2008; 247(1): 80 - 87. [Abstract] [Full Text] [PDF]