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Chronic Hypersensitivity Pneumonitis: CT Features—Comparison with Pathologic Evidence of Fibrosis and Survival¹

¹ From the Department of Radiology (H.S., V.H., D.A.L.), Department of Medicine (H.S., K.K.B., C.D.C.), and Division of Biostatistics (D.C.), National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206; Division of Pulmonary Sciences and Critical Care Medicine (K.K.B.), Departments of Preventive Medicine and Biometrics (D.C.), Physiology and Biophysics (D.C.), and Pathology (C.D.C.), University of Colorado at Denver and Health Sciences Center, Denver, Colo; and Department of Medicine, Inova Fairfax Hospital (Medical Critical Care Service), Falls Church, Va (J.S.V.). From the 2005 RSNA Annual Meeting. Received April 11, 2006; revision requested June 21; final revision received October 16; accepted November 3; final version accepted January 16, 2007. Supported by National Institutes of Health grant HL67671. Address correspondence to H.S. (e-mail: sahinh{at}njc.org).

Purpose: To retrospectively compare in patients with chronic hypersensitivity pneumonitis (HP) the computed tomographic (CT) imaging features suggestive of fibrosis with pathologic evidence of fibrosis at surgical lung biopsy and to compare a usual interstitial pneumonia (UIP) pattern at CT with survival.

Materials and Methods: Institutional review board approval and informed consent were obtained for this study, which was HIPAA compliant. Twenty-six patients (15 women, 11 men; age range, 37–76 years) with chronic HP had their surgical lung biopsy results reviewed by two pathologists for the presence of fibrosis. Two radiologists systematically reviewed the CT scans. The two radiologists were blinded to all clinical information, including pathologic diagnosis, patient information, and outcomes. The combination of a subpleural reticular pattern and lower zone predominance was considered a UIP pattern. CT findings were compared with the histopathologic presence of fibrosis, physiologic parameters, symptoms, and survival. The ² or Fisher exact test (each two-tailed) was used to compare nominal and ordinal variables. A t test (with unequal variances) was used to compare continuous variables. The log-rank procedure was used to compare Kaplan-Meier survival curves.

Results: Fifteen patients had fibrotic HP at biopsy, and 11 had nonfibrotic HP. Patients with fibrotic HP had more extensive reticular pattern and were more likely to have traction bronchiectasis, honeycombing, and a UIP pattern than those with nonfibrotic HP (P = .015, P = .007, P = .007, respectively). Although the presence of histologic fibrosis was associated with decreased survival (P = .003), the CT features were not associated with decreased survival.

Conclusion: CT findings of extensive reticular pattern, traction bronchiectasis, and honeycombing are closely related to the presence of histologic fibrosis in chronic HP.

© RSNA, 2007

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