Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print August 9, 2007, 10.1148/radiol.2443061397
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2443061397v1
244/3/736    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lessick, J.
Right arrow Articles by Ghersin, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lessick, J.
Right arrow Articles by Ghersin, E.
(Radiology 2007;244:736-744.)
© RSNA, 2007

Cardiac Imaging

Is Functional Improvement after Myocardial Infarction Predicted with Myocardial Enhancement Patterns at Multidetector CT?1

Jonathan Lessick, MD, DSc, Robert Dragu, MD, Diab Mutlak, MD, Shmuel Rispler, MD, DSc, Rafael Beyar, MD, DSc, Diana Litmanovich, MD, Ahuva Engel, MD, Yoram Agmon, MD, Michael Kapeliovich, MD, Haim Hammerman, MD, and Eduard Ghersin, MD

1 From the Departments of Cardiology (J.L., R.D., D.M., S.R., R.B., Y.A., M.K., H.H.) and Medical Imaging (D.L., A.E., E.G.), Rambam Health Care Campus, Haaliya St, Haifa 31096, Israel; and Technion-Israel Institute of Technology, Haifa, Israel (J.L., R.B., Y.A., H.H., A.E., E.G.). Received August 12, 2006; revision requested October 17; revision received November 14; accepted December 20; final version accepted January 15, 2007. Address correspondence to J.L. (e-mail: jlessick{at}rambam.health.gov.il).

Purpose: To prospectively evaluate the sensitivity of myocardial early perfusion defects (EDs) and late enhancement (LE) at multidetector computed tomography (CT) following acute myocardial infarction (AMI) to predict segment myocardial dysfunction and myocardial functional recovery (MFR), by using echocardiography as the reference standard.

Materials and Methods: Institutional review board approval and informed consent were obtained. Twenty-six patients (25 men, one woman; mean age, 53 years ± 9 [standard deviation]), underwent baseline multidetector CT, coronary angiography, and echocardiography within a week of AMI and a follow-up echocardiography at 3 months. ED, LE, and late hypoattenuation were compared with regional left ventricular function and MFR. A logistic regression model and generalized estimating equation analysis were applied to estimate the predictive effect of ED and LE. Differences between groups were evaluated by using nonpaired Student t tests.

Results: All EDs and LE corresponded with AMI location determined by using angiography and echocardiography. For occluded arteries (n = 5), no relationship was found between the presence of ED or LE and MFR. For patent arteries (n = 21), presence of LE had a respective sensitivity and specificity of 73% and 85% for predicting follow-up segment dysfunction, compared with 57% and 90% for ED. In abnormal baseline segments, nonrecovery was clearly related to the presence and size of segment defect area for both ED (odds ratio: 1.95 [95% confidence interval: 0.9, 4.1] per square centimeter) and LE (odds ratio: 1.85 [95% confidence interval: 1.2, 2.9] per square centimeter). Segments that recovered had significantly lower prevalence of ED and LE, and if present, were significantly smaller than in segments remaining abnormal (P < .05).

Conclusion: The presence and size of ED and LE at multidetector CT is closely related to follow-up segment myocardial dysfunction and MFR.

© RSNA, 2007




This article has been cited by other articles:


Home page
 RadiologyHome page
R. C. Cury, K. Nieman, M. D. Shapiro, J. Butler, C. H. Nomura, M. Ferencik, U. Hoffmann, S. Abbara, D. S. Jassal, T. Yasuda, et al.
Comprehensive Assessment of Myocardial Perfusion Defects, Regional Wall Motion, and Left Ventricular Function by Using 64-Section Multidetector CT
Radiology, August 1, 2008; 248(2): 466 - 475.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
L. F. Tops, S. C. Krishnan, J. D. Schuijf, M. J. Schalij, and J. J. Bax
Noncoronary applications of cardiac multidetector row computed tomography.
J. Am. Coll. Cardiol. Img., January 1, 2008; 1(1): 94 - 106.
[Abstract] [Full Text] [PDF]