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Metabolic Imaging of Myocardial Triglyceride Content: Reproducibility of ¹H MR Spectroscopy with Respiratory Navigator Gating in Volunteers¹

¹ From the Departments of Radiology (R.W.v.d.M., J.D., A.d.R., H.J.L.), Cardiology (J.J.B.), and Endocrinology (S.H., J.W.A.S., J.A.R.), Leiden University Medical Center, Albinusdreef 2, C2-S, 2333 ZA Leiden, the Netherlands; Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland (S.K.); Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M.S.); Philips Medical Systems, Cleveland, Ohio (M.S.); and Department of Endocrinology, Free University Medical Center, Amsterdam, the Netherlands (M.D., L.J.R.). Received November 7, 2006; revision requested January 11, 2007; revision received January 25; final version accepted March 7. Address correspondence to H.J.L. (e-mail: h.j.lamb{at}lumc.nl).

Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution and reproducibility of hydrogen 1 (¹H) magnetic resonance (MR) spectroscopy, with and without respiratory motion compensation based on navigator echoes, in the assessment of myocardial triglyceride content in the human heart. In 20 volunteers (14 men, six women; mean age ± standard error, 31 years ± 2.8 [range, 19–60 years]; body mass index, 19–30 kg/m²) without history of cardiovascular disease, ¹H MR spectroscopy of the myocardium was performed at rest, with and without respiratory motion compensation. Unsuppressed water signal linewidth changed from 11.9 Hz to 10.7 Hz (P < .001) with the use of the navigator, which indicated better spectral resolution. The navigator improved the intraclass correlation coefficient for the assessment of myocardial triglyceride content from 0.32 to 0.81. Therefore, the authors believe that respiratory motion correction is essential for reproducible assessment of myocardial triglycerides.

© RSNA, 2007

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