HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2451060951v1 245/2/483    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vullierme, M.-P. Articles by Vilgrain, V. Search for Related Content PubMed PubMed Citation Articles by Vullierme, M.-P. Articles by Vilgrain, V.

Malignant Intraductal Papillary Mucinous Neoplasm of the Pancreas: In Situ versus Invasive Carcinoma—Surgical Resectability¹

¹ From the Departments of Radiology (M.P.V., M.G., V.V.) and Pathology (A.C.) and the Fédération Médico Chirurgicale (P.H., A.S., D.O., P.L., P.R.), Beaujon Hospital, 100 boulevard général Leclerc, 92110 Clichy La Garenne, France. From the 2004 RSNA Annual Meeting. Received June 1, 2006; revision requested August 1; revision received October 2; accepted November 1; final version accepted March 7, 2007. Address correspondence to M.P.V. (e-mail: marie-pierre.vullierme{at}bjn.aphp.fr).

Purpose: To retrospectively evaluate computed tomographic (CT) findings in patients with in situ and invasive malignant intraductal papillary mucinous neoplasms (IPMNs) of the pancreas and to evaluate the accuracy for surgical resectability, with surgery and pathologic analysis as the reference standards.

Materials and Methods: Institutional review board approval was obtained, and the informed consent requirement was waived. Forty-six patients with malignant IPMN proved at pathologic examination of the surgically resected specimen (n = 44) or laparotomy (n = 2) underwent surgery after multidetector CT was performed. CT findings were retrospectively evaluated to determine if a pancreatic malignant IPMN tumor was present; to make this determination, CT criteria were used to differentiate in situ from invasive tumors and signs of unresectability (liver metastasis, vascular CT pattern of encasement, or regional lymph node metastasis). The extent of the vascular CT pattern of encasement was recorded for each patient (no obliteration of the fat plane, obliteration of the fat plane of <50%, or obliteration of the fat plane of 50%). Statistical analysis was performed with the ² and Student t tests.

Results: CT revealed a mural nodule in the pancreatic duct wall in 14 patients with in situ carcinoma and one patient with invasive carcinoma (P < .003). CT revealed an infiltrative pancreatic mass in 17 patients with invasive carcinoma and two patients with in situ carcinoma (P < .02). Of the mural nodules, 93% were seen in patients with in situ carcinoma, whereas 90% of infiltrative pancreatic masses were observed in patients with invasive carcinomas. The positive predictive value of CT for determining resectability was 100%, and the overall accuracy of CT for determining resectability and unresectability was 74%. The positive predictive value of CT for determining unresectability was 17%, mainly owing to overestimation of arterial invasion.

Conclusion: CT is helpful in the differentiation of in situ and invasive IPMN. Classic vascular invasion criteria lead to the overestimation of surgical tumor unresectability in patients with malignant IPMN.

© RSNA, 2007

This article has been cited by other articles:

				H. Ogawa, S. Itoh, M. Ikeda, K. Suzuki, and S. Naganawa Intraductal Papillary Mucinous Neoplasm of the Pancreas: Assessment of the Likelihood of Invasiveness with Multisection CT Radiology, September 1, 2008; 248(3): 876 - 886. [Abstract] [Full Text] [PDF]