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Published online before print October 2, 2007, 10.1148/radiol.2451061585
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(Radiology 2007;245:779-787.)
© RSNA, 2007

Gastrointestinal Imaging

Patient-specific Time to Peak Abdominal Organ Enhancement Varies with Time to Peak Aortic Enhancement at MR Imaging1

Lisa L. Chu, BA, Bonnie N. Joe, MD, PhD, Antonio C. A. Westphalen, MD, Emily M. Webb, MD, Fergus V. Coakley, MD, and Benjamin M. Yeh, MD

1 From the Department of Radiology, University of California-San Francisco, 505 Parnassus Ave, Box 0628, C-324C, San Francisco, CA 94143-0628. Received September 13, 2006; revision requested November 11; revision received January 5, 2007; final version accepted February 5. B.M.Y. received the ARRS/Philips Medical Systems Scholarship. Address correspondence to B.M.Y. (e-mail: ben.yeh{at}radiology.ucsf.edu).

Purpose: To retrospectively evaluate the relationship between the times to peak enhancement of the liver, pancreas, and jejunum with respect to the time to peak aortic enhancement at magnetic resonance (MR) imaging.

Materials and Methods: The committee on human research approved this study and waived written informed consent. This study was HIPAA compliant. The study retrospectively identified 141 patients (63 men, 78 women; mean age, 57 years) who underwent abdominal MR imaging by using a test bolus that was monitored approximately every second for 2 minutes with a spoiled gradient-echo T1 transverse section through the upper abdomen. The times to peak enhancement of the aorta, liver, pancreas, and jejunum were recorded and correlated with the time to peak aortic enhancement, age, and sex by means of univariate and multivariate linear regression analyses.

Results: The mean time to peak aortic enhancement was 21.1 seconds (range, 8.7–41.8 seconds). The times to peak enhancement of the liver, pancreas, and jejunum were positively and linearly correlated with the time to peak aortic enhancement (r = 0.69, 0.86, and 0.80, respectively, all P < .001) and were 3.39, 1.64, and 2.04 times longer than the time to peak aortic enhancement, respectively. Age, sex, and history of heart disease did not give additional predictive information for determining the time to peak visceral enhancement.

Conclusion: The times to peak enhancement of the liver, pancreas, and jejunum are linearly related to that of the aorta. These results could potentially allow tailored patient- and organ-specific scan delay optimization at contrast material–enhanced MR image evaluation.

© RSNA, 2007