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MR Myocardial Perfusion Imaging with k-Space and Time Broad-Use Linear Acquisition Speed-up Technique: Feasibility Study¹

¹ From the Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany (R.G., C.J., I.P., A.B., E.F., E.N.); Philips Medical Systems, Hamburg, Germany (B.S.); and Eidgenössische Technische Hochschule, Zürich, Switzerland (S.K.). Received October 4, 2006; revision requested December 6; revision received January 22, 2007; accepted March 1; final version accepted April 13. Address correspondence to R.G. (e-mail: gebker{at}dhzb.de).

The purpose of this study was to prospectively evaluate the diagnostic accuracy of a cardiovascular magnetic resonance (MR) k-space and time (k-t) broad-use linear acquisition speed-up technique (BLAST) accelerated perfusion sequence for depicting clinically relevant coronary artery disease (CAD), with use of coronary angiography as the reference standard. The local ethics committee approved this study, and informed consent was obtained from 40 patients (28 men, 12 women; mean age, 61 years ± 8 [standard deviation]) scheduled for coronary catheterization. A balanced steady-state free precession pulse sequence (2.6 x 2.6 x 10 mm) with a net k-t acceleration factor of 3.8 (repetition time msec/echo time msec, 3.2/1.6; flip angle, 50°) was applied. Visual analysis of perfusion images and quantitative analysis of signal-time curves obtained in the myocardium were performed by using segmental myocardial upslope, peak enhancement, and their respective ratios. Visual analysis revealed sensitivity, specificity, and diagnostic accuracy of 86%, 78%, and 83%, respectively, in the detection of coronary stenoses with at least 50% luminal narrowing. Significant (P < .05) changes between ischemic and remote segments could be shown for all perfusion indexes applied. Use of myocardial perfusion imaging with k-t BLAST for accelerated data acquisition is feasible in the identification of patients with substantial CAD (coronary stenosis 50%).

Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/245/3/863/DC1

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