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DOI: 10.1148/radiol.2461061994
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(Radiology 2008;246:20-32.)
© RSNA, 2008

Reviews

Imaging Genetics of Brain Longevity and Mental Wellness: The Next Frontier?1

Jeffrey R. Petrella, MD, Venkata S. Mattay, MD, and P. Murali Doraiswamy, MD

1 From the Alzheimer Imaging Research Laboratory, Department of Radiology (J.R.P.) and Department of Psychiatry and Medicine (P.M.D.), Duke University Medical Center, Box 3808, Durham, NC 27710; and Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, Md (V.S.M.). Received November 22, 2006; revision requested January 23, 2007; revision received February 19; accepted March 20; final version accepted May 7; final review by J.R.P. June 20. P.M.D. has received grants and consulting fees from pharmaceutical and diagnostic companies. Address correspondence to J.R.P. (e-mail: jeffrey.petrella{at}duke.edu).

The advent of new "omics" technologies (genomics, proteomics, and metabolomics) has ushered in a new era of biomedical discovery that is already affecting every field of medicine. With the rapid growth of the older population worldwide, there is great interest in applying these technologies not only to diagnose and prevent disease, but also to enhance brain longevity and mental wellness. Nearly two-thirds of the approximately 30 000 genes in the human genome are related to brain function, and up to half of the variance in age-related changes in cognition, brain volume, and neuronal function appears to be genetically determined. Selected examples will be used to illustrate how neuroimaging is being employed to study the effects of genes and how neurogenetics may affect future radiology research and practice.

© RSNA, 2008






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