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DOI: 10.1148/radiol.2463061900
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(Radiology 2008;246:258-264.)
© RSNA, 2007

Technical Developments

Cervical Spinal Cord Lesions in Multiple Sclerosis: T1-weighted Inversion-Recovery MR Imaging with Phase-Sensitive Reconstruction1

Aziz H. Poonawalla, PhD, Ping Hou, PhD, Flavia A. Nelson, MD, Jerry S. Wolinsky, MD, and Ponnada A. Narayana, PhD

1 From the Department of Diagnostic and Interventional Radiology (A.H.P., P.H., P.A.N.) and Department of Neurology (F.N., J.S.W.), The University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030. From the 2006 RSNA Annual Meeting. Received November 6, 2006; revision requested January 4, 2007; revision received January 24; accepted March 7; final version accepted April 19. Supported by National Institutes of Health grants R01 EB02095 and 1 S10 RR19186. Address correspondence to P.A.N. (e-mail: ponnada.a.narayana{at}uth.tmc.edu).

This magnetic resonance (MR) imaging study was approved by the institutional review board and was HIPAA compliant. Written informed consent was obtained from all participants. The purpose of the study was to prospectively compare T1-weighted inversion recovery with short inversion time inversion recovery (STIR) and dual fast spin echo (FSE) for imaging cervical spinal cord lesions in patients with multiple sclerosis (MS). Twelve patients (eight men, four women; median age, 44 years) were imaged by using T1-weighted inversion recovery, STIR, and FSE. Contrast between lesions and normal cervical cord was measured for each sequence, and generalized estimating equation analysis was used to test statistical significance of the results. Normalized contrast between lesion and normal-appearing spinal cord was significantly higher for T1-weighted inversion recovery than for the other sequences (P < .0001). Use of phase-sensitive reconstruction improved lesion localization and boundary definition. These advantages of T1-weighted inversion recovery over STIR and dual-echo FSE suggest that it has potential in cervical spinal cord imaging of MS.

© RSNA, 2007