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Cerebral Border Zones between Distal End Branches of Intracranial Arteries: MR Imaging¹

¹ From the Department of Radiology, University Medical Center Utrecht, Hp E 01.132, PO Box 85500, 3508 GA Utrecht, the Netherlands (J.H., P.J.v.L.); Department of Neuroradiology, National Neuroscience Institute, Singapore (E.T.P., X.G.); and MRI Facility, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore (X.G.). Received December 9, 2006; revision requested February 20, 2007; revision received March 23; accepted April 25; final version accepted July 2. Supported in part by Philips Medical Systems, the Netherlands Organization for Scientific Research, and the following Singapore grants: NMRC/0919/2004, NMRC/CPG/009/2004, and NHGA-RPR/04012. Address correspondence to J.H. (e-mail: j.hendrikse{at}umcutrecht.nl).

This study had institutional review board approval; informed consent was obtained from all participants. The study purpose was to prospectively determine whether a longer arterial transit time (ATT), from the proximal vasculature in the neck toward the distal end branches of the intracranial arteries, can be utilized to identify cerebral border zone regions. A magnetic resonance (MR) imaging method based on noninvasive arterial spin-labeling (ASL) perfusion MR imaging with image acquisition at a series of increasing delay times was used to quantify regional ATTs. Fifteen healthy volunteers (age range, 22–34 years; nine men, six women) were included. ASL perfusion MR imaging demonstrated an increase in ATT in the cerebral border zone regions, extending from the frontal and occipital horns of the lateral ventricle to the frontal and parietooccipital cortices, relative to ATT in non–border zone regions. Cerebral blood flow and arterial blood volume in these anterior and posterior border zone regions were significantly lower (P < .001) than in non–border zone regions.

© RSNA, 2007