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Published online before print January 14, 2008, 10.1148/radiol.2463070293
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(Radiology 2008;246:871-879.)
© RSNA, 2008

Neuroradiology

Intracranial Arteriovenous Malformation: Time-resolved Contrast-enhanced MR Angiography with Combination of Parallel Imaging, Keyhole Acquisition, and k-Space Sampling Techniques at 1.5 T1

Christian A. Taschner, MD, Jürgen Gieseke, PhD, Vianney Le Thuc, PhD, Henda Rachdi, MD, Nicolas Reyns, MD, Jean-Yves Gauvrit, MD, and Xavier Leclerc, MD

1 From the Departments of Neuroradiology (C.A.T., V.L.T., H.R., J.Y.G., X.L.) and Neurosurgery (N.R.), Hôpital Roger Salengro, University Hospital Lille, Rue Emile Laine, F-59037 Lille Cédex, France; and Philips Medical Systems, MR Clinical Science, Best, the Netherlands (J.G.). Received February 12, 2007; revision requested April 13; revision received June 12; accepted July 18; final version accepted August 30. C.A.T. supported by a research grant from the Swiss National Science Foundation that was funded by the L. + Th. Laroche Stiftung, Basel, Switzerland. Address correspondence to C.A.T. (e-mail: c.taschner{at}web.de).

Purpose: To prospectively compare the agreement between digital subtraction angiography (DSA) and time-resolved magnetic resonance (MR) angiography with sensitivity encoding (SENSE) in combination with keyhole acquisition and contrast material–enhanced robust-timing angiography (CENTRA) k-space sampling techniques for the characterization of intracranial arteriovenous malformations (AVMs).

Materials and Methods: The institutional review board approved the study; informed consent was obtained from all patients (or their parents). Twenty-eight patients (15 male, 13 female; mean age, 38.6 years; age range, 16–61 years) with 29 previously diagnosed, untreated intracranial AVMs who were referred for stereotactic gamma knife radiosurgery were evaluated. Preinterventional imaging included intraarterial DSA and time-resolved MR angiography. The time-resolved MR angiography sequence included SENSE with a 1.5-T imager and was optimized by applying keyhole acquisition and CENTRA techniques. Time-resolved MR angiograms were reviewed by two independent raters and compared with DSA images with regard to arterial feeders, nidus size, and venous drainage. {kappa} Statistics were applied to determine interobserver and intermodality agreement.

Results: MR angiography enabled time-resolved (1.7 seconds per volume) visualization of cerebral vessels from axis to vertex at high spatial resolution (true voxel size, 1 x 1 x 2 mm). All 25 nidi detected at intraarterial DSA were visualized at time-resolved MR angiography. Intermodality agreement was excellent for arterial feeders ({kappa} = 0.91; 95% confidence interval [CI]: 0.786, 1.000) and venous drainage ({kappa} = 0.94; 95% CI: 0.814, 1.000) and was good for nidus size ({kappa} = 0.76; 95% CI: 0.562, 0.950).

Conclusion: The agreement (good to excellent) between time-resolved MR angiographic and DSA findings suggests that time-resolved MR angiography is a reliable tool for the characterization of intracranial AVMs with respect to arterial feeders, nidus size, and venous drainage.

Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/2463070293/DC1

© RSNA, 2008