| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cardiac Imaging |
1 From the Department of Radiology (R.C.C., K.N., M.D.S., J.B., C.H.N., M.F., U.H., S.A., T.J.B.), Cardiology Division (D.S.J., T.Y., H.K.G., I.J.), and Cardiac MR-PET-CT Program (R.C.C., K.N., M.D.S., J.B., C.H.N., M.F., U.H., S.A., T.J.B.), Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Suite 400, Boston, MA 02114. From the 2006 RSNA Annual Meeting. Received August 19, 2007; revision requested October 8; revision received January 3, 2008; accepted February 4; final version accepted March 3. Supported in part by New York Cardiac Center, New York, NY, and Siemens Medical Solutions, Erlangen, Germany. M.F., M.D.S.; J.B. supported by NIH grant 1 T32 HL076136-02. K.N. supported by the Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands. Address correspondence to R.C.C. (e-mail: rcury{at}partners.org).
Purpose: To evaluate the accuracy of 64-section multidetector computed tomography (CT) for the assessment of perfusion defects (PDs), regional wall motion (RWM), and global left ventricular (LV) function.
Materials and Methods: All myocardial infarction (MI) patients signed informed consent. The IRB approved the study and it was HIPAA-compliant. Cardiac multidetector CT was performed in 102 patients (34 with recent acute MI and 68 without). Multidetector CT images were analyzed for myocardial PD, RWM abnormalities, and LV function. Global LV function and RWM were compared with transthoracic echocardiography (TTE) by using multidetector CT. PD was detected by using multidetector CT and was correlated with cardiac biomarkers and single photon emission CT (SPECT) myocardial perfusion imaging. Multidetector CT diagnosis of acute MI was made on the basis of matching the presence of PD with RWM abnormalities compared with clinical evaluation.
Results: Correlation between multidetector CT and TTE for global function (r = 0.68) and RWM (
= 0.79) was good. The size of PD on multidetector CT had a moderate correlation against SPECT (r = 0.48, –7% ± 9). There was good to excellent correlation between cardiac biomarkers and the percentage infarct size by using multidetector CT (r = 0.82 for creatinine phosphokinase, r = 0.76 for creatinine phosphokinase of the muscle band, and r = 0.75 for troponin). For detection of acute MI in patients, multidetector CT sensitivity was 94% (32 of 34) and specificity was 97% (66 of 68). Multidetector CT had an excellent interobserver reliability for ejection fraction quantification (r = 0.83), as compared with TTE (r = 0.68).
Conclusion: Patients with acute MI can be identified by using multidetector CT on the basis of RWM abnormalities and PD.
© RSNA, 2008
Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/248/2/466/DC1
This article has been cited by other articles:
|
|
 |
|
  S. Achenbach, V. Dilsizian, C. M. Kramer, and W. A. Zoghbi The Year in Coronary Artery Disease J. Am. Coll. Cardiol. Img., June 1, 2009; 2(6): 774 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ichikawa, K. Kitagawa, S. Chino, M. Ishida, K. Matsuoka, T. Tanigawa, T. Nakamura, T. Hirano, K. Takeda, and H. Sakuma Adipose tissue detected by multislice computed tomography in patients after myocardial infarction. J. Am. Coll. Cardiol. Img., May 1, 2009; 2(5): 548 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Hoffmann and F. Bamberg Is Computed Tomography Coronary Angiography the Most Accurate and Effective Noninvasive Imaging Tool to Evaluate Patients With Acute Chest Pain in the Emergency Department?: CT Coronary Angiography Is the Most Accurate and Effective Noninvasive Imaging Tool for Evaluating Patients Presenting With Chest Pain to the Emergency Department Circ Cardiovasc Imaging, May 1, 2009; 2(3): 251 - 263. [Full Text] [PDF]
|
|
