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DOI: 10.1148/radiol.2482071482
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(Radiology 2008;248:615-624.)
© RSNA, 2008

Technical Developments

Xenon Ventilation CT with a Dual-Energy Technique of Dual-Source CT: Initial Experience1

Eun Jin Chae, MD, Joon Beom Seo, MD, PhD, Hyun Woo Goo, MD, PhD, Namkug Kim, PhD, Koun-Sik Song, MD, PhD, Sang Do Lee, MD, PhD, Soo-Jong Hong, MD, PhD, and Bernhard Krauss, PhD

1 From the Department of Radiology and Research Institute of Radiology (E.J.C., J.B.S., H.W.G., N.K., K.S.S.), Department of Pulmonary and Critical Care Medicine (S.D.L.), and Department of Pediatrics (S.J.H.), University of Ulsan College of Medicine, Asan Medical Center, 388-1, Poongnap-dong, Songpa-gu, Seoul 138-736, Korea; and Siemens Medical Solutions, Forchheim, Germany (B.K.). Received August 20, 2007; revision requested October 5; revision received November 9; accepted December 21; final version accepted February 1, 2008. Supported by grants from the Korean Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A040153) and from the Asan Institute for Life Sciences, Seoul, Korea (2007-337). Address correspondence to J.B.S. (e-mail: seojb{at}amc.seoul.kr).

Institutional review board approval and written informed consent were obtained. Although xenon (Xe) ventilation CT has been introduced as a potential method with which to depict regional ventilation, quantification of Xe enhancement has been limited by the variability of lung attenuation caused by different lung volumes between scans. The purpose of this study was to assess the feasibility of Xe ventilation CT with a dual-energy technique. Dual-energy CT was performed in 12 subjects after Xe inhalation. With use of a dual-energy technique, the Xe component could be extracted without any influence from lung volume. Dynamic and static regional ventilation function can be displayed with an exact match to the thin-section CT image.

© RSNA, 2008

Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/248/2/615/DC1




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