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DOI: 10.1148/radiol.2483071927
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(Radiology 2008;248:1028-1035.)
© RSNA, 2008

Technical Developments

Simultaneous MR/PET Imaging of the Human Brain: Feasibility Study1

Heinz-Peter W. Schlemmer, MD, PhD, Bernd J. Pichler, MD, Matthias Schmand, PhD, Ziad Burbar, MD, Christian Michel, MD, Ralf Ladebeck, MD, Kirstin Jattke, MD, David Townsend, PhD, Claude Nahmias, MD, Pradeep K. Jacob, MD, Wolf-Dieter Heiss, MD, and Claus D. Claussen, MD

1 From the Department of Diagnostic Radiology, University Hospital Tübingen, Hoppe-Seyler-Strasse 3, D-72076 Tübingen, Germany (H.W.S., B.J.P., C.D.C.); Department of Molecular Imaging, Siemens Medical Solutions, Knoxville, Tenn (M.S., Z.B., C.M.); Department of Magnetic Resonance, Siemens Medical Solutions, Erlangen, Germany (R.L., K.J.); Molecular Imaging and Translational Research Program, University of Tennessee Graduate School of Medicine, Knoxville, Tenn (D.T., C.N.); Department of Radiology, University of Tennessee Medical Center, Knoxville, Tenn (P.K.J.); and Max Planck Institute for Neurological Research, Cologne, Germany (W.D.H.). Received November 12, 2007; revision requested January 23, 2008; revision received March 25; accepted April 21; final version accepted April 24. Address correspondence to H.P.S. (e-mail: heinz-peter.schlemmer{at}med.uni-tuebingen.de).

The purpose of this study was to apply a magnetic resonance (MR) imaging–compatible positron emission tomographic (PET) detector technology for simultaneous MR/PET imaging of the human brain and skull base. The PET detector ring consists of lutetium oxyorthosilicate (LSO) scintillation crystals in combination with avalanche photodiodes (APDs) mounted in a clinical 3-T MR imager with use of the birdcage transmit/receive head coil. Following phantom studies, two patients were simultaneously examined by using fluorine 18 fluorodeoxyglucose (FDG) PET and MR imaging and spectroscopy. MR/PET data enabled accurate coregistration of morphologic and multifunctional information. Simultaneous MR/PET imaging is feasible in humans, opening up new possibilities for the emerging field of molecular imaging.

© RSNA, 2008




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