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Published online before print August 18, 2008, 10.1148/radiol.2483072003
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(Radiology 2008;249:301-306.)
© RSNA, 2008

Technical Developments

Calcified Plaque: Measurement of Area at Thin-Section Flat-Panel CT and 64-Section Multidetector CT and Comparison with Histopathologic Findings1

Ammar Sarwar, MD, Johannes Rieber, MD, Eline A. Q. Mooyaart, MS, Sujith K. Seneviratne, MBBS, Stuart L. Houser, MD, Fabian Bamberg, MD, O. Christopher Raffel, MD, Rajiv Gupta, PhD, MD, Mannudeep K. Kalra, MD, Homer Pien, PhD, Hang Lee, PhD, Thomas J. Brady, MD, and Udo Hoffmann, MD, MPH

1 From the Cardiac MR PET CT Program, Massachusetts General Hospital, 165 Cambridge St, 4th Floor, Suite 400, Boston, MA 02114. Received November 19, 2007; revision requested January 16, 2008; final revision received February 19; accepted March 5; final version accepted March 19. Address correspondence to U.H. (e-mail: uhoffmann{at}partners.org).

The purpose of this study was to assess the blooming artifacts in ex vivo coronary arteries at multidetector computed tomography (CT) and flat-panel–volume CT by comparing measured areas of calcified plaque with respect to the reference standard of histopathologic findings. Three ex vivo hearts were scanned with multidetector CT and flat-panel–volume CT after institutional review board approval. The area of calcified plaque was measured at histopathologic examination, multidetector CT, and flat-panel–volume CT. The plaque area was overestimated at multidetector CT by 400% (4.61/1.15) on average, and the predicted difference between the measurements was significant (3.46 mm2, P = .018). The average overestimation of plaque area at flat-panel–volume CT was twofold (214% [2.18/1.02]), and the predicted difference was smaller (1.16 mm2, P = .08). The extent of the blooming artifact in visualizing calcified coronary plaque is reduced by using flat-panel–volume CT.

© RSNA, 2008




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