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k-Space and Time Sensitivity Encoding–accelerated Myocardial Perfusion MR Imaging at 3.0 T: Comparison with 1.5 T¹

¹ From the Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland (S.P., P.B., S.K.); Academic Unit of Cardiovascular Medicine, G-floor Jubilee Wing, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, United Kingdom (S.P., J.P.G.); and University Hospital Zurich, Zurich, Switzerland (J.S., D.S.). Received January 4, 2008; revision requested February 14; revision received April 17; accepted April 28; final version accepted May 15. Supported by Philips Medical Systems (Best, the Netherlands) and Bayer Schering Pharma (Zurich, Switzerland). S.P. supported by a Wellcome Trust fellowship (grant no. GR078288RR). Address correspondence to S.P. (e-mail: s.plein{at}leeds.ac.uk).

Purpose: To determine the feasibility and diagnostic accuracy of high-spatial-resolution myocardial perfusion magnetic resonance (MR) imaging at 3.0 T by using k-space and time (k-t) domain undersampling with sensitivity encoding (SENSE), or k-t SENSE. Data were compared with results of k-t SENSE–accelerated high-spatial-resolution perfusion MR imaging at 1.5 T and standard-resolution acquisition at 3.0 T.

Materials and Methods: The study was reviewed and approved by the local ethics review board; informed consent was obtained. k-t SENSE perfusion MR imaging was performed at 1.5 and 3.0 T (fivefold k-t SENSE acceleration; spatial resolution, 1.3 x 1.3 x 10 mm). Fourteen volunteers were studied at rest; 37 patients were studied during adenosine-induced stress. In volunteers, comparison was also made with standard-resolution (2.5 x 2.5 x 10 mm) twofold SENSE perfusion MR imaging results at 3.0 T. Image quality, artifact scores, signal-to-noise ratios (SNRs), and contrast enhancement ratios were derived. In patients, diagnostic accuracy of visual analysis to detect stenosis of more than 50% narrowing in diameter at quantitative coronary angiography was determined by using receiver operator characteristic (ROC) analysis.

Results: In volunteers, image quality and artifact scores were similar for 3.0- and 1.5-T k-t SENSE perfusion MR imaging, while SNR was higher (11.6 vs 5.6) and contrast enhancement ratio was lower (1.1 vs 1.5, P = .012) at 3.0 T. Compared with standard-resolution perfusion MR imaging, image quality was higher for 3.0-T k-t SENSE (3.6 vs 3.1, P = .04), endocardial dark rim artifacts were reduced (artifact thickness, 1.6 vs 2.4 mm, P < .001), and contrast enhancement ratios were similar. In patients, areas under the ROC curve for detection of coronary stenosis were 0.89 and 0.80 (P = .21) for 3.0 and 1.5 T, respectively.

Conclusion: k-t SENSE–accelerated high-spatial-resolution perfusion MR imaging at 3.0 T is feasible, with similar artifacts and diagnostic accuracy as those at 1.5 T. Compared with standard-resolution twofold SENSE perfusion MR imaging, image quality at k-t SENSE MR imaging is improved and artifacts are reduced.

© RSNA, 2008