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Visualization of Cerebrospinal Fluid Movement with Spin Labeling at MR Imaging: Preliminary Results in Normal and Pathophysiologic Conditions¹

¹ From the Departments of Neurosurgery (S.Y.) and Radiology (Y.M.), Tokai University at Oiso Hospital, Kanagawa, Japan; Department of Clinical Research, MR Toshiba Medical Research Institute USA, 706 N Deerpath Dr, Vernon Hills, IL 60061 (M.M.); MRI Department, Toshiba Medical Systems, Tochigi, Japan (H.K.); MRI Applications, Toshiba Medical Systems, Kanagawa, Japan (M.H.); Department of Radiology, Children's Hospital Los Angeles and the Keck School of Medicine, University of Southern California, Los Angeles, Calif (S.B.); Rudi Schulte Research Institute, Santa Barbara, Calif (S.B.); and Division of Neurosurgery, Children's Hospital Los Angeles and the Department of Neurological Surgery Keck School of Medicine, University of Southern California, Los Angeles, Calif (J.G.M.). Received November 14, 2007; revision requested January 10, 2008; revision received March 7; accepted April 30; final version accepted May 13. Supported by a grant from Toshiba Medical Systems. Address correspondence to M.M. (e-mail: mmiyazaki{at}tams.com).

Institutional review board approval and informed consent were obtained for this study. This study was HIPAA compliant. The purpose of this study was to visualize the movement of cerebrospinal fluid (CSF) noninvasively by using an unenhanced magnetic resonance imaging technique. A time-spatial labeling inversion pulse (SLIP) technique was applied to label, or tag, CSF in a region of interest. The tagged CSF was clearly visualized at inversion times of 1500–4500 msec after pulse labeling in both intracranial and intraspinal compartments. Noninvasive visualization of CSF movement, including bulk and turbulent flow, in normal (n = 7) and altered (n = 2) physiologic conditions was possible by using the unenhanced time-SLIP technique.

Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/249/2/644/DC1

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