HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Table E1 MPEG Movie Figure E1 All Versions of this Article: 2492072033v1 249/2/701    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Hadizadeh, D. R. Articles by Willinek, W. A. PubMed PubMed Citation Articles by Hadizadeh, D. R. Articles by Willinek, W. A.

Peripheral MR Angiography with Blood Pool Contrast Agent: Prospective Intraindividual Comparative Study of High-Spatial-Resolution Steady-State MR Angiography versus Standard-Resolution First-Pass MR Angiography and DSA¹

¹ From the Departments of Radiology (D.R.H., J.G., S.H.L., K.W., J.B., H.H.S., W.A.W.) and Vascular Surgery (F.V.), University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany; and Philips Medical Systems, Best, the Netherlands (J.G.). Received November 20, 2007; revision requested January 21, 2008; revision received March 6; accepted April 18; final version accepted May 21. Address correspondence to W.A.W. (e-mail: Winfried.Willinek{at}ukb.uni-bonn.de).

Purpose: To prospectively compare the accuracy of high-spatial-resolution steady-state magnetic resonance (MR) angiography with standard-resolution first-pass MR angiography in the lower extremities, with digital subtraction angiography (DSA) as the reference standard.

Materials and Methods: Institutional ethics committee approval and written informed consent were obtained. Twenty-seven patients (16 men, 11 women; mean age, 64.4 years ± 14.8 [standard deviation]; range, 26–87 years) suspected of having or known to have peripheral arterial disease underwent first-pass and steady-state MR angiography and DSA. First-pass and steady-state MR angiography were performed in the same patient in the same session and with the same dose of blood pool contrast agent. The most severe stenosis grade of each evaluated segment was measured; sensitivity, specificity, and positive and negative predictive values were calculated at first-pass and steady-state MR angiography, with DSA as the reference standard. The coefficient was used to measure the agreement between first-pass MR angiography, steady-state MR angiography, and DSA.

Results: A total of 334 arterial segments were available for intraindividual comparison of first-pass MR angiography, steady-state MR angiography, and DSA in 27 patients. In 20 (74%) of 27 patients, the stenosis grade of at least one of the evaluated vessels differed at steady-state MR angiography from that at first-pass MR angiography. In total, stenosis grade was judged as higher at first-pass MR angiography than at DSA (overestimation) in 28 of 334 segments and as lower (underestimation) in 15 of 334 segments. The stenosis grade as judged at steady-state MR angiography matched with that at DSA in 334 of 334 vessel segments.

Conclusion: High-spatial-resolution steady-state MR angiography allowed for better agreement with DSA regarding stenosis grade in patients with arterial disease compared with standard-resolution arterial-phase first-pass MR angiography.

Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/2492072033/DC1
http://radiology.rsnajnls.org/cgi/content/full/2492072033/DC2
http://radiology.rsnajnls.org/cgi/content/full/2492072033/DC3

© RSNA, 2008