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Cyclosporin A–induced Fibroadenomas of the Breast: Report of Five Cases¹

¹ From the Departments of Radiology (S.P.W., S.G.O., E.F.C.) and Surgery (B.C.), University of Pennsylvania Medical Center, 3400 Spruce St, 1 Silverstein Bldg, Philadelphia, PA 19104; the Department of Radiology, Crozer-Chester Medical Center, Upland, Pa (L.C.); and the Division of Hospital Pathology, University of Washington Medical Center, Seattle (T.J.L.). Received June 13, 2000; revision requested July 24; revision received December 22; accepted January 23, 2001. Address correspondence to S.P.W.

View larger version (96K): [in a new window]   Figure 1a. Mediolateral oblique mammograms in a 34-year-old female patient. Views of (a) the normal left breast and (b) the normal right breast obtained prior to renal transplant. (c, d) Mammograms obtained 16 months after renal transplantation and cyclosporin A therapy, demonstrate (c) the left breast and (d) the right breast, both with newly developed multiple bilateral circumscribed masses.

View larger version (87K): [in a new window]   Figure 1b. Mediolateral oblique mammograms in a 34-year-old female patient. Views of (a) the normal left breast and (b) the normal right breast obtained prior to renal transplant. (c, d) Mammograms obtained 16 months after renal transplantation and cyclosporin A therapy, demonstrate (c) the left breast and (d) the right breast, both with newly developed multiple bilateral circumscribed masses.

View larger version (118K): [in a new window]   Figure 1c. Mediolateral oblique mammograms in a 34-year-old female patient. Views of (a) the normal left breast and (b) the normal right breast obtained prior to renal transplant. (c, d) Mammograms obtained 16 months after renal transplantation and cyclosporin A therapy, demonstrate (c) the left breast and (d) the right breast, both with newly developed multiple bilateral circumscribed masses.

View larger version (111K): [in a new window]   Figure 1d. Mediolateral oblique mammograms in a 34-year-old female patient. Views of (a) the normal left breast and (b) the normal right breast obtained prior to renal transplant. (c, d) Mammograms obtained 16 months after renal transplantation and cyclosporin A therapy, demonstrate (c) the left breast and (d) the right breast, both with newly developed multiple bilateral circumscribed masses.

View larger version (121K): [in a new window]   Figure 2a. Images in same patient as in (a) Transverse US image of the left breast shows multiple well-circumscribed solid masses (arrows). (b) Sagittal fast spin-echo T2-weighted nonenhanced MR image (5,000/84) of the left breast reveals a lobulated mass of intermediate signal intensity with internal septa (arrows). (c) Sagittal three-dimensional gadolinium-enhanced fast spoiled gradient-echo MR image of the left breast demonstrates two lobulated masses (arrows). The superior one corresponds to the mass in b. Both masses demonstrate contrast enhancement and low-signal-intensity nonenhancing septa that are suggestive of fibroadenomas.

View larger version (162K): [in a new window]   Figure 2b. Images in same patient as in (a) Transverse US image of the left breast shows multiple well-circumscribed solid masses (arrows). (b) Sagittal fast spin-echo T2-weighted nonenhanced MR image (5,000/84) of the left breast reveals a lobulated mass of intermediate signal intensity with internal septa (arrows). (c) Sagittal three-dimensional gadolinium-enhanced fast spoiled gradient-echo MR image of the left breast demonstrates two lobulated masses (arrows). The superior one corresponds to the mass in b. Both masses demonstrate contrast enhancement and low-signal-intensity nonenhancing septa that are suggestive of fibroadenomas.

View larger version (108K): [in a new window]   Figure 2c. Images in same patient as in (a) Transverse US image of the left breast shows multiple well-circumscribed solid masses (arrows). (b) Sagittal fast spin-echo T2-weighted nonenhanced MR image (5,000/84) of the left breast reveals a lobulated mass of intermediate signal intensity with internal septa (arrows). (c) Sagittal three-dimensional gadolinium-enhanced fast spoiled gradient-echo MR image of the left breast demonstrates two lobulated masses (arrows). The superior one corresponds to the mass in b. Both masses demonstrate contrast enhancement and low-signal-intensity nonenhancing septa that are suggestive of fibroadenomas.

View larger version (125K): [in a new window]   Figure 3a. Mammograms in a 60-year-old renal transplant recipient with a mass in the left breast. Subsequent biopsy revealed a fibroadenoma. (a) Normal mediolateral oblique view of the left breast obtained in 1997. (b) Mediolateral oblique view of the left breast obtained in 1998 shows a newly developed mass (arrow) in the posterior breast.

View larger version (121K): [in a new window]   Figure 3b. Mammograms in a 60-year-old renal transplant recipient with a mass in the left breast. Subsequent biopsy revealed a fibroadenoma. (a) Normal mediolateral oblique view of the left breast obtained in 1997. (b) Mediolateral oblique view of the left breast obtained in 1998 shows a newly developed mass (arrow) in the posterior breast.