Published online before print October 30, 2001, 10.1148/radiol.2221001154
Longitudinal Follow-up Study of Smoker’s Lung with Thin-Section CT in Correlation with Pulmonary Function Tests1
Martine Remy-Jardin, MD, PhD,
Jean-Louis Edme, PhD,
Charles Boulenguez, MD,
Jacques Remy, MD,
Ioana Mastora, MD and
Annie Sobaszek, MD, PhD
1 From the Department of Radiology, Calmette University Center Hospital, Blvd Jules Leclerc, 59037 Lille, France (M.R.J., J.R., I.M.); the Medical Research Group, Equipe d’Accueil no. 2682, Lille, France (M.R.J., J.R.); and the Environmental and Occupational Health and Ergonomics Research Center, University of Lille, France (J.L.E., C.B., A.S.). From the 2000 RSNA scientific assembly. Received June 30, 2000; revision requested August 28; revision received April 23, 2001; accepted May 22. Address correspondence to M.R.J. (e-mail: mremy-jardin@chru-lille.fr).
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Figure 1a. CT scans from a 6-year longitudinal study in a 29-year-old persistent current smoker (23.0 pack-years at T0; 29.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows areas of hypoattenuation (arrowheads) disseminated throughout the upper lung zone, suggestive of emphysematous lesions. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows extensive emphysematous changes (arrowheads) in both lungs and more prominent septal lines. Note the long posterior junction line (arrow), suggestive of lung distention.
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Figure 1b. CT scans from a 6-year longitudinal study in a 29-year-old persistent current smoker (23.0 pack-years at T0; 29.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows areas of hypoattenuation (arrowheads) disseminated throughout the upper lung zone, suggestive of emphysematous lesions. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows extensive emphysematous changes (arrowheads) in both lungs and more prominent septal lines. Note the long posterior junction line (arrow), suggestive of lung distention.
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Figure 2a. CT scans from a 6-year longitudinal study in a 27-year-old persistent current smoker (9.0 pack-years at T0; 17.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules (arrowheads) and areas of mild ground-glass attenuation in the central and peripheral parts of the upper lung zone. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows numerous ill-defined micronodules (arrowheads) diffusely distributed throughout both lungs.
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Figure 2b. CT scans from a 6-year longitudinal study in a 27-year-old persistent current smoker (9.0 pack-years at T0; 17.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules (arrowheads) and areas of mild ground-glass attenuation in the central and peripheral parts of the upper lung zone. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows numerous ill-defined micronodules (arrowheads) diffusely distributed throughout both lungs.
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Figure 3a. CT scans from a 7-year longitudinal study in a 33-year-old persistent current smoker (7.5 pack-years at T0; 16.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules (arrowheads) in the upper lung zone. (b) Transverse thin-section CT scan obtained at the same level as in a at T1 shows numerous nodular areas of increased attenuation (arrowheads), some depicted with a patent centrilobular distribution and more prominent septal lines.
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Figure 3b. CT scans from a 7-year longitudinal study in a 33-year-old persistent current smoker (7.5 pack-years at T0; 16.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules (arrowheads) in the upper lung zone. (b) Transverse thin-section CT scan obtained at the same level as in a at T1 shows numerous nodular areas of increased attenuation (arrowheads), some depicted with a patent centrilobular distribution and more prominent septal lines.
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Figure 4a. CT scans from a 5-year longitudinal study in a 31-year-old persistent current smoker (15.0 pack-years at T0; 21.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules (arrowheads) in the upper lung zone. Arrows points to subpleural emphysematous area. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows replacement of the micronodular pattern (arrowheads) observed in a in the peripheral part of the anterior segment by small areas of hypoattenuation indicative of emphysematous changes, also observed in the central part of the lung. No change in the subpleural emphysematous area (arrow) is seen.
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Figure 4b. CT scans from a 5-year longitudinal study in a 31-year-old persistent current smoker (15.0 pack-years at T0; 21.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules (arrowheads) in the upper lung zone. Arrows points to subpleural emphysematous area. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows replacement of the micronodular pattern (arrowheads) observed in a in the peripheral part of the anterior segment by small areas of hypoattenuation indicative of emphysematous changes, also observed in the central part of the lung. No change in the subpleural emphysematous area (arrow) is seen.
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Figure 5a. CT scans from a 6-year longitudinal study in a 34-year-old persistent current smoker (30.0 pack-years at T0; 38.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules in the upper lung zones. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows replacement of the micronodular pattern by numerous small areas of hypoattenuation, indicative of emphysematous changes.
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Figure 5b. CT scans from a 6-year longitudinal study in a 34-year-old persistent current smoker (30.0 pack-years at T0; 38.0 pack-years at T1). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules in the upper lung zones. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows replacement of the micronodular pattern by numerous small areas of hypoattenuation, indicative of emphysematous changes.
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Figure 6a. CT images from a 7-year longitudinal study in a 41-year-old quitter (20.0 pack-years at T0). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules (arrowheads) in the upper lung zones. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows considerable reduction in the profusion of ill-defined micronodules (arrowheads).
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Figure 6b. CT images from a 7-year longitudinal study in a 41-year-old quitter (20.0 pack-years at T0). (a) Transverse thin-section CT scan targeted to the right lung at T0 shows faint parenchymal micronodules (arrowheads) in the upper lung zones. (b) Transverse thin-section CT scan obtained at the same level as a at T1 shows considerable reduction in the profusion of ill-defined micronodules (arrowheads).
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Copyright © 2002 by the Radiological Society of North America.
