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Differences between Computer-aided Diagnosis of Breast Masses and That of Calcifications¹

¹ From the Departments of Biomedical Engineering and Radiology, Digital Imaging Research Division, Duke University Medical Center, DUMC 3302, Durham, NC 27710. Received July 23, 2001; revision requested September 4; revision received October 12; accepted December 10. Supported in part by U.S. Public Health Service grants R29-CA75547, R21-CA092573, and R21-CA81309 awarded by the National Cancer Institute; Whitaker Foundation grants RG-97-0322 and SO-97-0035; U.S. Army Medical Research and Materiel Command grant DAMD17-99-1-9174 awarded by the U.S. Army; and Susan G. Komen Breast Cancer Foundation grants 9803 and BCTR2000730A. Address correspondence to M.K.M. (e-mail: markey@duke.edu).

View larger version (29K): [in a new window]   Figure 1. ROC curves for the mammographers’ assessment of the likelihood of malignancy in the cases from Duke University Medical Center. The mammographers’ assessment was more accurate for masses than for calcifications. FPF = false-positive fraction, TPF = true-positive fraction.

View larger version (30K): [in a new window]   Figure 2. ROC curves for the BP-ANN in the cases from Duke University Medical Center. BP-ANN was more accurate for masses than for calcifications. FPF = false-positive fraction, TPF = true-positive fraction.

View larger version (30K): [in a new window]   Figure 3. ROC curves for the LDA in the cases from Duke University Medical Center. LDA was more accurate for masses than for calcifications. FPF = false-positive fraction, TPF = true-positive fraction.

View larger version (30K): [in a new window]   Figure 4. ROC curves for the BP-ANN in the cases from the University of Pennsylvania Medical Center. BP-ANN was more accurate for masses than for calcifications. FPF = false-positive fraction, TPF = true-positive fraction.