HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Guo, A. C. Articles by Provenzale, J. M. Search for Related Content PubMed PubMed Citation Articles by Guo, A. C. Articles by Provenzale, J. M.

Lymphomas and High-Grade Astrocytomas: Comparison of Water Diffusibility and Histologic Characteristics¹

¹ From the Departments of Radiology (A.C.G., J.M.P.) and Pathology (T.J.C., R.C.D.), Duke University Medical Center, Box 3808, Durham, NC 27710. From the 2000 RSNA scientific assembly. Received March 19, 2001; revision requested April 19; final revision received December 27; accepted January 15, 2002. Address correspondence to J.M.P.

View larger version (132K): [in a new window]   Figure 1a. (a-c) MR images obtained in a 60-year-old woman with primary CNS lymphoma. (a) Transverse T1-weighted image (500/11) obtained after administration of gadopentetate dimeglumine shows an enhancing mass (arrow) in the medial right occipital lobe, extending into the splenium of the corpus callosum. (b) Transverse diffusion-weighted spin-echo echo-planar MR image (12,000/100/2,200; diffusion gradient in three orthogonal directions; b = 1,000 sec/mm2) obtained at the same anatomic level as a shows high signal intensity (arrow) within the enhancing tumor. (c) Transverse ADC map at the same level as a and b shows low signal intensity (black arrow) within the enhancing tumor and high signal intensity in peritumoral edema (white arrows). The ADClym/ADCwm ratio measured in this tumor was 1.10. (d) An optically magnified image of a section of lymphoma shows a dense aggregate of cells with scanty cytoplasm and extracellular matrix. The N/C ratio measured in this tumor was 3.13. (Hematoxylin-eosin stain; original magnification, x18.)

View larger version (102K): [in a new window]   Figure 1b. (a-c) MR images obtained in a 60-year-old woman with primary CNS lymphoma. (a) Transverse T1-weighted image (500/11) obtained after administration of gadopentetate dimeglumine shows an enhancing mass (arrow) in the medial right occipital lobe, extending into the splenium of the corpus callosum. (b) Transverse diffusion-weighted spin-echo echo-planar MR image (12,000/100/2,200; diffusion gradient in three orthogonal directions; b = 1,000 sec/mm2) obtained at the same anatomic level as a shows high signal intensity (arrow) within the enhancing tumor. (c) Transverse ADC map at the same level as a and b shows low signal intensity (black arrow) within the enhancing tumor and high signal intensity in peritumoral edema (white arrows). The ADClym/ADCwm ratio measured in this tumor was 1.10. (d) An optically magnified image of a section of lymphoma shows a dense aggregate of cells with scanty cytoplasm and extracellular matrix. The N/C ratio measured in this tumor was 3.13. (Hematoxylin-eosin stain; original magnification, x18.)

View larger version (102K): [in a new window]   Figure 1c. (a-c) MR images obtained in a 60-year-old woman with primary CNS lymphoma. (a) Transverse T1-weighted image (500/11) obtained after administration of gadopentetate dimeglumine shows an enhancing mass (arrow) in the medial right occipital lobe, extending into the splenium of the corpus callosum. (b) Transverse diffusion-weighted spin-echo echo-planar MR image (12,000/100/2,200; diffusion gradient in three orthogonal directions; b = 1,000 sec/mm2) obtained at the same anatomic level as a shows high signal intensity (arrow) within the enhancing tumor. (c) Transverse ADC map at the same level as a and b shows low signal intensity (black arrow) within the enhancing tumor and high signal intensity in peritumoral edema (white arrows). The ADClym/ADCwm ratio measured in this tumor was 1.10. (d) An optically magnified image of a section of lymphoma shows a dense aggregate of cells with scanty cytoplasm and extracellular matrix. The N/C ratio measured in this tumor was 3.13. (Hematoxylin-eosin stain; original magnification, x18.)

View larger version (152K): [in a new window]   Figure 1d. (a-c) MR images obtained in a 60-year-old woman with primary CNS lymphoma. (a) Transverse T1-weighted image (500/11) obtained after administration of gadopentetate dimeglumine shows an enhancing mass (arrow) in the medial right occipital lobe, extending into the splenium of the corpus callosum. (b) Transverse diffusion-weighted spin-echo echo-planar MR image (12,000/100/2,200; diffusion gradient in three orthogonal directions; b = 1,000 sec/mm2) obtained at the same anatomic level as a shows high signal intensity (arrow) within the enhancing tumor. (c) Transverse ADC map at the same level as a and b shows low signal intensity (black arrow) within the enhancing tumor and high signal intensity in peritumoral edema (white arrows). The ADClym/ADCwm ratio measured in this tumor was 1.10. (d) An optically magnified image of a section of lymphoma shows a dense aggregate of cells with scanty cytoplasm and extracellular matrix. The N/C ratio measured in this tumor was 3.13. (Hematoxylin-eosin stain; original magnification, x18.)

View larger version (130K): [in a new window]   Figure 2a. (a-c) MR images obtained in a 70-year-old man with glioblastoma multiforme. (a) Transverse T1-weighted MR image (500/11) obtained after administration of gadopentetate dimeglumine shows a ring-enhancing mass in the left temporal lobe with a relatively solid component (arrow) at the posterior aspect of the mass. (b) Transverse diffusion-weighted spin-echo echo-planar MR image (12,000/100/2,200; diffusion gradient in three orthogonal directions; b = 1,000 sec/mm2) obtained at the same anatomic level as a shows low signal intensity (arrow) within the solid posterior portion of the tumor. (c) Transverse ADC map at the same level as a and b shows high signal intensity (arrow) within the solid posterior portion of the tumor. The ADCast/ADCwm ratio measured in this tumor was 1.83. 1 = ROI used to obtain ADC value in this lesion. (d) An optically magnified image of a section of glioblastoma multiforme shows a less dense aggregate of cells compared with that in Figure 1 and more abundant cytoplasm and extracellular matrix. The N/C ratio measured in this tumor was 0.357. (Hematoxylin-eosin stain; original magnification, x18.)

View larger version (108K): [in a new window]   Figure 2b. (a-c) MR images obtained in a 70-year-old man with glioblastoma multiforme. (a) Transverse T1-weighted MR image (500/11) obtained after administration of gadopentetate dimeglumine shows a ring-enhancing mass in the left temporal lobe with a relatively solid component (arrow) at the posterior aspect of the mass. (b) Transverse diffusion-weighted spin-echo echo-planar MR image (12,000/100/2,200; diffusion gradient in three orthogonal directions; b = 1,000 sec/mm2) obtained at the same anatomic level as a shows low signal intensity (arrow) within the solid posterior portion of the tumor. (c) Transverse ADC map at the same level as a and b shows high signal intensity (arrow) within the solid posterior portion of the tumor. The ADCast/ADCwm ratio measured in this tumor was 1.83. 1 = ROI used to obtain ADC value in this lesion. (d) An optically magnified image of a section of glioblastoma multiforme shows a less dense aggregate of cells compared with that in Figure 1 and more abundant cytoplasm and extracellular matrix. The N/C ratio measured in this tumor was 0.357. (Hematoxylin-eosin stain; original magnification, x18.)

View larger version (122K): [in a new window]   Figure 2c. (a-c) MR images obtained in a 70-year-old man with glioblastoma multiforme. (a) Transverse T1-weighted MR image (500/11) obtained after administration of gadopentetate dimeglumine shows a ring-enhancing mass in the left temporal lobe with a relatively solid component (arrow) at the posterior aspect of the mass. (b) Transverse diffusion-weighted spin-echo echo-planar MR image (12,000/100/2,200; diffusion gradient in three orthogonal directions; b = 1,000 sec/mm2) obtained at the same anatomic level as a shows low signal intensity (arrow) within the solid posterior portion of the tumor. (c) Transverse ADC map at the same level as a and b shows high signal intensity (arrow) within the solid posterior portion of the tumor. The ADCast/ADCwm ratio measured in this tumor was 1.83. 1 = ROI used to obtain ADC value in this lesion. (d) An optically magnified image of a section of glioblastoma multiforme shows a less dense aggregate of cells compared with that in Figure 1 and more abundant cytoplasm and extracellular matrix. The N/C ratio measured in this tumor was 0.357. (Hematoxylin-eosin stain; original magnification, x18.)

View larger version (129K): [in a new window]   Figure 2d. (a-c) MR images obtained in a 70-year-old man with glioblastoma multiforme. (a) Transverse T1-weighted MR image (500/11) obtained after administration of gadopentetate dimeglumine shows a ring-enhancing mass in the left temporal lobe with a relatively solid component (arrow) at the posterior aspect of the mass. (b) Transverse diffusion-weighted spin-echo echo-planar MR image (12,000/100/2,200; diffusion gradient in three orthogonal directions; b = 1,000 sec/mm2) obtained at the same anatomic level as a shows low signal intensity (arrow) within the solid posterior portion of the tumor. (c) Transverse ADC map at the same level as a and b shows high signal intensity (arrow) within the solid posterior portion of the tumor. The ADCast/ADCwm ratio measured in this tumor was 1.83. 1 = ROI used to obtain ADC value in this lesion. (d) An optically magnified image of a section of glioblastoma multiforme shows a less dense aggregate of cells compared with that in Figure 1 and more abundant cytoplasm and extracellular matrix. The N/C ratio measured in this tumor was 0.357. (Hematoxylin-eosin stain; original magnification, x18.)

View larger version (70K): [in a new window]   Figure 3. Bar graph shows a comparison of mean ADC ratio of CNS lymphomas with that of high-grade (HG) astrocytomas, and it shows a comparison of mean N/C ratio of CNS lymphomas with that of high-grade astrocytomas. Error bars represent 1 SD from the mean. The mean ADC ratio and the mean N/C ratio are inversely related: Mean ADC ratio of lymphomas is lower than mean ADC ratio of high-grade astrocytomas, whereas mean N/C ratio of lymphomas is higher than mean N/C ratio of high-grade astrocytomas.