DOI: 10.1148/radiol.2241011005
Multiple Sclerosis: Low-Frequency Temporal Blood Oxygen Level–Dependent Fluctuations Indicate Reduced Functional Connectivity—Initial Results1
Mark J. Lowe, PhD,
Micheal D. Phillips, MD,
Joseph T. Lurito, MD, PhD,
David Mattson, MD, PhD,
Mario Dzemidzic, PhD and
Vincent P. Mathews, MD
1 From the Departments of Radiology (M.J.L., M.D.P., J.T.L., M.D., V.P.M.) and Neurology (D.M.), Indiana University School of Medicine, CL 157, 541 Clinical Dr, Indianapolis, IN 46202-5111. Received June 6, 2001; revision requested July 23; final revision received January 4, 2002; accepted January 15. Supported in part by a grant from the Whitaker Foundation. Address correspondence to M.J.L. (e-mail: mjlowe@iupui.edu).
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Figure 1. MT-prepared 5-mm-thick sagittal gradient-echo MR images (106/5 with flip angle of 12°). To select the volume of the middle portion of the corpus callosum, two lines were drawn so that one was tangential to the inferior splenium and genu and the other passed through the mamillary bodies while perpendicularly intersecting the first line. A 90° arc was then centered on the vertical line to form the anterior and posterior boundaries of the midline volume of interest.
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Figure 2. Anatomic images 1-10. The midline volume of interest was determined on images 5 and 6 by using the cingulate gyrus as the superior border and the inferior aspect of the corpus callosum as the inferior border. This volume of interest was then projected on images 4 and 7, 5 mm posterior and 5 mm superior to its initial position; on images 3 and 8, 10 mm posterior and 10 mm superior; on images 2 and 9, 15 mm posterior and 15 mm superior; and on images 1 and 10, 20 mm posterior and 20 mm superior. The final volume of interest (white box) was designed to approximate the course of callosal fibers that connect the primary motor cortices.
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Figure 4. Graphs depict the distribution of MT ratio (MTR) for 12 control subjects and 12 patients with MS measured in the (A) entire corpus callosum and periventricular white matter and (B) in a region of interest in the corpus callosum (see Materials and Methods for the description of the region of interest). Data are shown for all patients for whom MTR data were collected.
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Figure 5. Plot of MT ratio (MTR) measured in the corpus callosum and surrounding periventricular white matter versus EDSS for 12 patients with MS. No significant correlation is observed between the two variables. Data are shown for all patients for whom MTR data were collected.
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Figure 6. Plot of MT ratio (MTR) measured in the corpus callosum versus EDSS for 12 patients with MS. No significant correlation was observed between the two variables. Data are shown for all patients for whom MTR data were collected.
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Figure 7. Graphs depict the distribution (A) in the resting state and (B) with continuous finger tapping of the fraction of pixels in the right precentral gyrus that are above a 95% confidence level for correlation with low-frequency BOLD fluctuations in the left precentral gyrus.
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Figure 8. Plots in (left) patients with MS and (right) control subjects depict the fraction of pixels in a region of interest in the right precentral gyrus (PCG) that are above a 95% confidence level for correlation with low-frequency BOLD fluctuations in a region of interest in the left precentral gyrus during continuous finger tapping versus the resting state. Regions of interest were defined on the basis of results in a motor study with functional MR imaging. The regions below the dashed lines contain data for more than 60% of the patients and for none of the control subjects.
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Copyright © 2002 by the Radiological Society of North America.
t 
10 = color range from red to yellow.