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Is the Spatial Distribution of Brain Lesions Associated with Closed-Head Injury in Children Predictive of Subsequent Development of Posttraumatic Stress Disorder?¹

¹ From the Division of Neuroradiology, Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21287-7619 (E.H.H., C.D.); Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, Md (E.H.H.); Department of Psychiatry, Johns Hopkins Bayview Medical Center, Baltimore, Md (J.P.G.); and Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia (R.N.B.). Received August 28, 2001; revision requested October 17; revision received December 21; accepted February 25, 2002. Supported by the Human Brain Project, National Institutes of Health grant R01 AG13743, which is funded by the National Institute of Aging, the National Institute of Mental Health, the National Aeronautics and Space Administration, and the National Cancer Institute. E.H.H. supported by a Richard S. Ross Clinician Scientist Award. The BRAID project is supported by a software grant from Informix. Address correspondence to E.H.H.

View larger version (157K): [in a new window]   Figure 1a. Transverse summary MR images obtained at the level of the genu of the corpus callosum, just above the frontal horns of (a) the lateral ventricles and (b) the hippocampi depict all lesions summed over all subjects (lesions are yellow, cortex [mapped against the Talairach stereotaxic atlas] is blue).

View larger version (149K): [in a new window]   Figure 1b. Transverse summary MR images obtained at the level of the genu of the corpus callosum, just above the frontal horns of (a) the lateral ventricles and (b) the hippocampi depict all lesions summed over all subjects (lesions are yellow, cortex [mapped against the Talairach stereotaxic atlas] is blue).

View larger version (156K): [in a new window]   Figure 2a. Transverse MR images at the level of the hippocampi depict all lesions in subjects who (a) did not and (b) did develop the reexperiencing symptom complex of PTSD (lesions are yellow, cortex [mapped against the Talairach stereotaxic atlas] is blue, hippocampi are red).

View larger version (149K): [in a new window]   Figure 2b. Transverse MR images at the level of the hippocampi depict all lesions in subjects who (a) did not and (b) did develop the reexperiencing symptom complex of PTSD (lesions are yellow, cortex [mapped against the Talairach stereotaxic atlas] is blue, hippocampi are red).