Published online before print July 19, 2002, 10.1148/radiol.2243011236
Drug-induced Pneumonitis: Thin-Section CT Findings in 60 Patients1
Masanori Akira, MD,
Hideo Ishikawa, MD and
Satoru Yamamoto, MD
1 From the Departments of Radiology (M.A.), Medicine (H.I.), and Pathology (S.Y.), National Kinki Chuo Hospital for Chest Disease, 1180 Nagasone-cho, Sakai City, Osaka 591-8555, Japan. Received July 20, 2001; revision requested September 24; final revision received March 11, 2002; accepted March 25. Address correspondence to M.A. (e-mail: akira@kinchu.hosp.go.jp).
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Figure 1. Docetaxel-induced pneumonitis in a 60-year-old man. Transverse thin-section CT scan shows multifocal areas of ground-glass opacity with intralobular interstitial thickening (arrows).
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Figure 2. CPT-11-induced pneumonitis in a 70-year-old man. Transverse thin-section CT scan shows extensive area of ground-glass opacity with both intralobular interstitial thickening and interlobular septal lines (arrowheads).
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Figure 3. Gemcitabine-induced pneumonitis in a 66-year-old man. Transverse thin-section CT scan shows patchy ground-glass opacity with intralobular interstitial thickening. Prominent interlobular septal lines (arrows) are also observed.
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Figure 4a. Minocycline-induced pneumonitis in a 63-year-old man. (a) Initial transverse thin-section CT scan shows fine nodules and branching lines (arrows), mainly in centrilobular distribution. (b) Follow-up transverse thin-section CT scan obtained after rechallenge shows increase in areas of ground-glass opacity (arrowheads).
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Figure 4b. Minocycline-induced pneumonitis in a 63-year-old man. (a) Initial transverse thin-section CT scan shows fine nodules and branching lines (arrows), mainly in centrilobular distribution. (b) Follow-up transverse thin-section CT scan obtained after rechallenge shows increase in areas of ground-glass opacity (arrowheads).
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Figure 5. Isoniazid-induced pneumonitis in a 45-year-old woman. Transverse thin-section CT scan shows patchy ground-glass opacity with interlobular septal lines and centrilobular nodules and branching lines (arrows).
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Figure 6. Rifampin-induced pneumonitis in a 39-year-old man. Transverse thin-section CT scans show generalized smooth interlobular septal thickening (arrows) with areas of ground-glass opacity (arrowheads).
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Figure 7. Pneumonitis induced with herbal medicine, sho-saiko-to, in a 51-year-old man. Transverse thin-section CT scan shows area of ground-glass opacity with intralobular interstitial thickening with patchy consolidation (arrows).
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Figure 8. Gold sodium thiomalate-induced pneumonitis in a 50-year-old man. Transverse thin-section CT scan shows patchy ground-glass opacity with interlobular septal lines (white arrowheads) and centrilobular nodules and branching lines (black arrowheads).
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Figure 9. Graph shows correlation between arterial oxygen tension level and extent of disease at CT in 21 patients. There is significant inverse correlation between arterial oxygen tension level and extent of disease at CT.
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Copyright © 2002 by the Radiological Society of North America.
