Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print August 12, 2002, 10.1148/radiol.2251011555
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johkoh, T.
Right arrow Articles by Nakamura, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johkoh, T.
Right arrow Articles by Nakamura, H.

Nonspecific Interstitial Pneumonia: Correlation between Thin-Section CT Findings and Pathologic Subgroups in 55 Patients1

Takeshi Johkoh, MD, PhD, Nestor L. Müller, MD, PhD, Thomas V. Colby, MD, Kazuya Ichikado, MD, PhD, Hiroyuki Taniguchi, MD, PhD, Yasuhiro Kondoh, MD, PhD, Kiminori Fujimoto, MD, PhD, Masaharu Kinoshita, MD, PhD, Hiroaki Arakawa, MD, PhD, Hidehiro Yamada, MD, PhD, Moritaka Suga, MD, PhD, Masayuki Ando, MD, PhD, Mitsuhiro Koyama, MD and Hironobu Nakamura, MD, PhD

1 From the Dept of Radiology, Osaka Univ Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0825, Japan (T.J., M. Koyama, H.N.); Dept of Radiology, Univ of British Columbia and Vancouver Hosp and Health Sciences Centre, Canada (N.L.M.); Dept of Pathology and Laboratory Medicine, Mayo Clinic Scottsdale, Ariz (T.V.C.); First Dept of Internal Medicine, Kumamoto Univ School of Medicine, Japan (K.I., M.S., M.A.); Dept of Respiratory Medicine, Tosei General Hosp, Aichi, Japan (H.T., Y.K.); Depts of Radiology (K.F.) and Internal Medicine (M. Kinoshita), Kurume Univ School of Medicine, Fukuoka, Japan; Dept of Radiology, Dokkyo Univ School of Medicine, Tochigi, Japan (H.A.); and Dept of Internal Medicine, St Marianna Univ School of Medicine, Kanagawa, Japan (H.Y.). Received Sept 19, 2001; revision requested Nov 23; final revision received Mar 1, 2002; accepted Mar 28. Address correspondence to T.J. (e-mail: johkoh@radiol.med.osaka-u.ac.jp).



View larger version (112K):

[in a new window]
  		Figure 1a. Group 1 (grade 1) NIP in a 51-year-old woman. (a) Transverse thin-section CT image (1-mm collimation) obtained at the level of the dome of the right hemidiaphragm demonstrates diffuse areas with ground-glass attenuation. Areas of air-space consolidation that predominantly distribute along bronchovascular bundles are also seen. A few peripheral small bronchioles show traction bronchiectasis (arrows). (b) Histologic section (hematoxylin-eosin stain; original magnification, x10) demonstrates cellular interstitial pneumonia distributed homogeneously. This appearance is compatible with group 1 NIP.

 


View larger version (155K):

[in a new window]
  		Figure 1b. Group 1 (grade 1) NIP in a 51-year-old woman. (a) Transverse thin-section CT image (1-mm collimation) obtained at the level of the dome of the right hemidiaphragm demonstrates diffuse areas with ground-glass attenuation. Areas of air-space consolidation that predominantly distribute along bronchovascular bundles are also seen. A few peripheral small bronchioles show traction bronchiectasis (arrows). (b) Histologic section (hematoxylin-eosin stain; original magnification, x10) demonstrates cellular interstitial pneumonia distributed homogeneously. This appearance is compatible with group 1 NIP.

 


View larger version (107K):

[in a new window]
  		Figure 2a. Group 2 (grade 2) cellular NIP in a 59-year-old woman. (a) Transverse thin-section CT image (1-mm collimation) obtained through the right lung base shows diffuse areas of air-space consolidation. Areas with ground-glass attenuation and liner opacities (arrows) are also seen. Traction bronchiectasis (arrowheads) can be seen in peripheral areas. (b) Histologic section (hematoxylin-eosin stain; original magnification, x10) demonstrates cellular interstitial pneumonia and a relatively small amount of intraluminal immature fibrosis. This appearance is compatible with group 2 cellular NIP.

 


View larger version (143K):

[in a new window]
  		Figure 2b. Group 2 (grade 2) cellular NIP in a 59-year-old woman. (a) Transverse thin-section CT image (1-mm collimation) obtained through the right lung base shows diffuse areas of air-space consolidation. Areas with ground-glass attenuation and liner opacities (arrows) are also seen. Traction bronchiectasis (arrowheads) can be seen in peripheral areas. (b) Histologic section (hematoxylin-eosin stain; original magnification, x10) demonstrates cellular interstitial pneumonia and a relatively small amount of intraluminal immature fibrosis. This appearance is compatible with group 2 cellular NIP.

 


View larger version (141K):

[in a new window]
  		Figure 3a. Group 2 (grade 3) fibrotic NIP in a 48-year-old woman. (a) Transverse thin-section CT image (1-mm collimation) obtained at the level of the dome of the right hemidiaphragm demonstrates areas of air-space consolidation predominantly distributed along bronchovascular bundles. Areas with ground-glass attenuation and intralobular reticular opacities (arrows) are also seen. Traction bronchiectasis (arrowheads) is distributed more widely and located in more proximal areas than those in grades 1 and 2 NIP. (b) Histologic section (hematoxylin-eosin stain; original magnification, x10) demonstrates a relatively large amount of fibrosis (arrows) and small amount of cellular infiltrates in alveolar walls. This appearance is compatible with group 2 fibrotic NIP.

 


View larger version (140K):

[in a new window]
  		Figure 3b. Group 2 (grade 3) fibrotic NIP in a 48-year-old woman. (a) Transverse thin-section CT image (1-mm collimation) obtained at the level of the dome of the right hemidiaphragm demonstrates areas of air-space consolidation predominantly distributed along bronchovascular bundles. Areas with ground-glass attenuation and intralobular reticular opacities (arrows) are also seen. Traction bronchiectasis (arrowheads) is distributed more widely and located in more proximal areas than those in grades 1 and 2 NIP. (b) Histologic section (hematoxylin-eosin stain; original magnification, x10) demonstrates a relatively large amount of fibrosis (arrows) and small amount of cellular infiltrates in alveolar walls. This appearance is compatible with group 2 fibrotic NIP.

 


View larger version (103K):

[in a new window]
  		Figure 4a. Group 3 (grade 4) NIP in a 48-year-old woman. (a) Transverse thin-section CT image (1-mm collimation) obtained at the level of the dome of the right hemidiaphragm demonstrates diffuse areas with ground-glass attenuation. Widely distributed traction bronchiectasis (arrows) and a small amount of honeycombing (arrowheads) are also seen. (b) Histologic section (hematoxylin-eosin stain; original magnification, x5) demonstrates homogeneous areas with fibrosis (arrows). This appearance is compatible with group 3 NIP.

 


View larger version (129K):

[in a new window]
  		Figure 4b. Group 3 (grade 4) NIP in a 48-year-old woman. (a) Transverse thin-section CT image (1-mm collimation) obtained at the level of the dome of the right hemidiaphragm demonstrates diffuse areas with ground-glass attenuation. Widely distributed traction bronchiectasis (arrows) and a small amount of honeycombing (arrowheads) are also seen. (b) Histologic section (hematoxylin-eosin stain; original magnification, x5) demonstrates homogeneous areas with fibrosis (arrows). This appearance is compatible with group 3 NIP.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 2002 by the Radiological Society of North America.