Published online before print August 12, 2002, 10.1148/radiol.2251011042
Benign Solitary Solid Cold Thyroid Nodules: US-guided Interstitial Laser Photocoagulation— Initial Experience1
Helle Døssing, MD,
Finn Noe Bennedbæk, MD, PhD,
Steen Karstrup, MD, PhD and
Laszlo Hegedüs, MD, DMSc
1 From the Departments of Otorhinolaryngology (H.D.) and Endocrinology (F.N.B., L.H.), Odense University Hospital, Sdr Boulevard 29, DK-5000 Odense C, Denmark; and the Department of Diagnostic Radiology, Roskilde Hospital, University of Copenhagen, Denmark (S.K.). Received June 14, 2001; revision requested July 5; final revision received March 25, 2002; accepted April 9. Supported by the Agnes and Knut Mørk Foundation and the A. P. Møller Relief Foundation. Address correspondence to L.H. (e-mail: laszlo.hegedus@ouh.fyns-amt.dk).
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Figure 1a. Longitudinal US scans of the neck of a 47-year-old treated female patient show a solid nodule in the left thyroid lobe (a) before, (b) during, and (c) at 1 month after ILP. Cursors indicate the outer margins of the nodule. In b, which was obtained 60 seconds after ILP had been initiated, a cylindrical echogenic area is seen centrally (arrows). In c, a hyperechogenic area representing scar tissue is seen in the center of the nodule (arrows). A small rim was untreated in the proximal and caudal part of the nodule (area between arrow and cursor). The scale is in centimeters.
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Figure 1b. Longitudinal US scans of the neck of a 47-year-old treated female patient show a solid nodule in the left thyroid lobe (a) before, (b) during, and (c) at 1 month after ILP. Cursors indicate the outer margins of the nodule. In b, which was obtained 60 seconds after ILP had been initiated, a cylindrical echogenic area is seen centrally (arrows). In c, a hyperechogenic area representing scar tissue is seen in the center of the nodule (arrows). A small rim was untreated in the proximal and caudal part of the nodule (area between arrow and cursor). The scale is in centimeters.
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Figure 1c. Longitudinal US scans of the neck of a 47-year-old treated female patient show a solid nodule in the left thyroid lobe (a) before, (b) during, and (c) at 1 month after ILP. Cursors indicate the outer margins of the nodule. In b, which was obtained 60 seconds after ILP had been initiated, a cylindrical echogenic area is seen centrally (arrows). In c, a hyperechogenic area representing scar tissue is seen in the center of the nodule (arrows). A small rim was untreated in the proximal and caudal part of the nodule (area between arrow and cursor). The scale is in centimeters.
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Figure 2. Graph shows thyroid nodule volume before and at 1, 3, and 6 months after treatment. Data are given as means and standard errors of the means. There was a significant reduction in thyroid nodule volume from 0 to 6 months (P < .001).
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Figure 3. Graph shows the relationship between energy deposition and reduction in thyroid nodule volume at 6-month follow-up in 16 patients treated with ILP. No correlation between the energy deposition and reduction in thyroid nodule volume is seen.
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Figure 4. Graph shows the pressure symptom and cosmetic complaint ratings—determined with the visual analogue scale—before and at 6 months after ILP. Data are given as medians and SDs. A significant reduction in pressure symptoms is evident (P < .0002).
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Copyright © 2002 by the Radiological Society of North America.
