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Published online before print October 24, 2002, 10.1148/radiol.2253020053
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Long-term Prognostic Value of Dobutamine Stress 99mTc-Sestamibi SPECT: Single-Center Experience with 8-year Follow-up1

Arend F. L. Schinkel, MD, Abdou Elhendy, MD, Ron T. van Domburg, PhD, Jeroen J. Bax, MD, Roelf Valkema, MD, Jos R. T. C. Roelandt, MD and Don Poldermans, MD

1 From the Departments of Cardiology (A.F.L.S., A.E. R.T.v.D., J.R.T.C.R., D.P.) and Nuclear Medicine (R.V.), Erasmus Medical Center Rotterdam, Dr Molewaterplein 40, Thoraxcenter Rm Ba 300, 3015 GD Rotterdam, the Netherlands, and the Department of Cardiology, Leiden University Medical Center, the Netherlands (J.J.B.). Received February 14, 2002; revision requested March 7; revision received May 6; accepted June 25. Address correspondence to D.P. (e-mail: poldermans@hlkd.azr.nl).



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  		Figure 1. Kaplan-Meier survival curves for cardiac death according to results of dobutamine stress 99mTc-sestamibi SPECT. The curves indicate that patients with normal stress images maintained a low event rate up to 8 years after stress testing.

 


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  		Figure 2. Kaplan-Meier survival curves for cardiac events (cardiac death, nonfatal MI, or revascularization), according to results of dobutamine stress 99mTc-sestamibi SPECT. The annual cardiac event rate was significantly lower in patients with normal perfusion.

 


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  		Figure 3. Bar graph shows incremental prognostic value of dobutamine stress 99mTc-sestamibi SPECT over clinical data. Dobutamine stress 99mTc-sestamibi SPECT provided significant prognostic information in addition to clinical data alone.

 


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  		Figure 4. Bar graph shows cumulative cardiac event (cardiac death, nonfatal MI, or revascularization) rates per year according to SSS. An abnormal perfusion pattern, as well as the SSS, provided additional incremental prognostic information.

 




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