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Published online before print August 30, 2002, 10.1148/radiol.2251011938

(Radiology 2002;225:71.)

A more recent version of this article appeared on October 1, 2002
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Prostate: High-Frequency Doppler US Imaging for Cancer Detection1

Ethan J. Halpern, MD, Ferdinand Frauscher, MD, Stephen E. Strup, MD, Levon N. Nazarian, MD, Patrick O’Kane, MD and Leonard G. Gomella, MD

1 From the Departments of Radiology (E.J.H., F.F., L.N.N., P.O.) and Urology (S.E.S., L.G.G.), Jefferson Prostate Diagnostic Center, Thomas Jefferson University, 132 S 10th St, Philadelphia, PA 19107-5244. Received November 27, 2001; revision requested January 17, 2002; revision received January 29; accepted February 28. Address correspondence to E.J.H. (e-mail: ethan.halpern@mail.tju.edu).



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  		Figure 1. Graph depicts ROC curves for the detection of prostate cancer at gray-scale ({blacksquare}), color Doppler ({bullet}), and power Doppler ({blacktriangleup}) imaging.

 


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  		Figure 2a. Transverse (a) color Doppler and (b) power Doppler US images of the prostate at midgland level in a 59-year-old man. Doppler flow (arrows) is increased posteriorly in the midline on color and power Doppler images. Three of four targeted biopsy cores were positive for cancer of the prostate (Gleason score, 7) in the midline (n = 2) and the right portion of the base (n = 1). One of six sextant cores was also positive for cancer in the right portion of the base.

 


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  		Figure 2b. Transverse (a) color Doppler and (b) power Doppler US images of the prostate at midgland level in a 59-year-old man. Doppler flow (arrows) is increased posteriorly in the midline on color and power Doppler images. Three of four targeted biopsy cores were positive for cancer of the prostate (Gleason score, 7) in the midline (n = 2) and the right portion of the base (n = 1). One of six sextant cores was also positive for cancer in the right portion of the base.

 


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  		Figure 3a. Transverse (a) color Doppler and (b) power Doppler US images of the prostate at midgland level in a 71-year-old man. Doppler flow (arrows) is increased in a capsular vessel along the right portion of the midgland on color and power Doppler images. Small perforating branches from this capsular vessel enter the peripheral zone. Increased flow (arrowheads) is also demonstrated in the enlarged transition zone. Three of four targeted biopsy cores were positive for cancer (Gleason score, 6 or 7) of the prostate in the right portion of the midgland. All sextant biopsy cores were negative.

 


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  		Figure 3b. Transverse (a) color Doppler and (b) power Doppler US images of the prostate at midgland level in a 71-year-old man. Doppler flow (arrows) is increased in a capsular vessel along the right portion of the midgland on color and power Doppler images. Small perforating branches from this capsular vessel enter the peripheral zone. Increased flow (arrowheads) is also demonstrated in the enlarged transition zone. Three of four targeted biopsy cores were positive for cancer (Gleason score, 6 or 7) of the prostate in the right portion of the midgland. All sextant biopsy cores were negative.

 


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  		Figure 4a. Transverse (a) color Doppler and (b) power Doppler US images of the midgland of the prostate in a 54-year-old man. Increased Doppler flow (arrows) is identified along the left side of the prostate with both color and power Doppler imaging. All four targeted biopsy cores on the left side were negative. A positive sextant core was obtained from the right portion of the midgland.

 


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  		Figure 4b. Transverse (a) color Doppler and (b) power Doppler US images of the midgland of the prostate in a 54-year-old man. Increased Doppler flow (arrows) is identified along the left side of the prostate with both color and power Doppler imaging. All four targeted biopsy cores on the left side were negative. A positive sextant core was obtained from the right portion of the midgland.

 




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